Molecular structure of Probucol, CAS Number: 23288-49-5
Probucol (CAS 23288-49-5)
See product citations (5)
Alternate Names:
Bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole acetone
Application:
Probucol is an antioxidant, anti-inflammatory, and hypocholesterolemic agent which inhibits atherogenesis in murine models
CAS Number:
23288-49-5
Purity:
≥98%
Molecular Weight:
516.84
Molecular Formula:
C31H48O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Probucol is utilized in research focusing on its antioxidant properties, particularly in studies related to oxidative stress and its effects on various biological systems. Probucol is of interest in the field of material science, where it is used to enhance the stability of polymers against degradation by oxygen and other oxidative agents. Probucol is studied for its role in the protection of cellular components from oxidative damage, which is useful for understanding the aging process and the longevity of cells under stress conditions. In environmental science, its effectiveness in preventing oxidative deterioration in industrial materials is also a subject of study, aiming to develop more durable and sustainable materials.
Probucol (CAS 23288-49-5) References
- Probucol. | Pfuetze, KD. and Dujovne, CA. 2000. Curr Atheroscler Rep. 2: 47-57. PMID: 11122724
- Probucol and its mechanisms for reducing atherosclerosis. | Jackson, RL., et al. 1991. Adv Exp Med Biol. 285: 367-72. PMID: 1858568
- Where are we with probucol: a new life for an old drug? | Yamashita, S. and Matsuzawa, Y. 2009. Atherosclerosis. 207: 16-23. PMID: 19457483
- Effects of probucol on restenosis after percutaneous coronary intervention: a systematic review and meta-analysis. | Liu, J., et al. 2015. PLoS One. 10: e0124021. PMID: 25898372
- Did we abandon probucol too soon? | Yamashita, S., et al. 2015. Curr Opin Lipidol. 26: 304-16. PMID: 26125504
- Probucol. A reappraisal of its pharmacological properties and therapeutic use in hypercholesterolaemia. | Buckley, MM., et al. 1989. Drugs. 37: 761-800. PMID: 2667936
- Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production. | Zucoloto, AZ., et al. 2017. Eur J Pharmacol. 809: 52-63. PMID: 28501577
- Probucol in long-term treatment of hypercholesterolemia. | Strandberg, TE., et al. 1988. Gen Pharmacol. 19: 317-20. PMID: 3046993
- Probucol Protects Neuronal Cells Against Peroxide-Induced Damage and Directly Activates Glutathione Peroxidase-1. | Santos, DB., et al. 2020. Mol Neurobiol. 57: 3245-3257. PMID: 32506382
- The Combination Treatment of Curcumin and Probucol Protects Chondrocytes from TNF-α Induced Inflammation by Enhancing Autophagy and Reducing Apoptosis via the PI3K-Akt-mTOR Pathway. | Han, G., et al. 2021. Oxid Med Cell Longev. 2021: 5558066. PMID: 34257809
- Protective Effects of Probucol on Different Brain Cells Exposed to Manganese. | da Silva, EB., et al. 2022. Neurotox Res. 40: 276-285. PMID: 35043377
- Probucol promotes osteoblasts differentiation and prevents osteoporosis development through reducing oxidative stress. | Tao, ZS., et al. 2022. Mol Med. 28: 75. PMID: 35764958
- Probucol as an antioxidant and antiatherogenic drug. | Kuzuya, M. and Kuzuya, F. 1993. Free Radic Biol Med. 14: 67-77. PMID: 8454225
Inhibitor of:
AADACL1, ABC-A1, ABCG1, Afamin, apoA-II, apoB48R, APOC (Apolipoprotein C), apoE, apoF, apoM, APOP1, DSCD75, EG624219, FA2H, LCAT, LDLR, LIMP I, Lmf1, MENTHO, OATP-I, SCARF (scavenger receptor class F), SCP-2, SLC22A29, SOAT2, STARD, StARD10, and TMEM195.Activator of:
apoA, ORP-5, OSBP2, Pmp24, and SR-BI.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Probucol, 100 mg | sc-203666 | 100 mg | $79.00 | |||
Probucol, 1 g | sc-203666A | 1 g | $166.00 |