Molecular structure of Probenecid, CAS Number: 57-66-9
Probenecid (CAS 57-66-9)
See product citations (28)
Alternate Names:
p-(Dipropylsulfamoyl)benzoic acid
Application:
Probenecid is an inhibitor of several ABC-transporters of the subfamily ABCC or MRP
CAS Number:
57-66-9
Purity:
≥97%
Molecular Weight:
285.36
Molecular Formula:
C13H19NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Probenecid is an inhibitor of MRP1 (multidrug resistance-associated proteins). This compound blocks the active site of MRP1 and prevents cellular efflux of other active compounds, enhancing their effectiveness by allowing them to remain in the cytoplasm. Probenecid is an inhibitor of Pannexin-1. it is also a potently selective agonist of TRPV2 (transient receptor potential vanilloid 2) channels.
Probenecid (CAS 57-66-9) References
- Once-daily cefazolin and probenecid for skin and soft tissue infections. | Cox, VC. and Zed, PJ. 2004. Ann Pharmacother. 38: 458-63. PMID: 14970368
- Influence of probenecid on the delivery of morphine-6-glucuronide to the brain. | Tunblad, K., et al. 2005. Eur J Pharm Sci. 24: 49-57. PMID: 15626577
- Probenecid, a gout remedy, inhibits pannexin 1 channels. | Silverman, W., et al. 2008. Am J Physiol Cell Physiol. 295: C761-7. PMID: 18596212
- Inhibition of 2-methoxyestradiol glucuronidation by probenecid. | Qian, Y., et al. 2015. J Pharm Pharmacol. 67: 1585-92. PMID: 26272356
- Probenecid protects against oxygen-glucose deprivation injury in primary astrocytes by regulating inflammasome activity. | Jian, Z., et al. 2016. Brain Res. 1643: 123-9. PMID: 27154322
- Probenecid directly impairs activation of the canine P2X7 receptor. | Bartlett, R., et al. 2017. Nucleosides Nucleotides Nucleic Acids. 36: 736-744. PMID: 29200326
- Effect of probenecid on the disposition of captopril and captopril dimer in the rat. | Drummer, OH., et al. 1985. Biochem Pharmacol. 34: 3347-51. PMID: 2994681
- Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2. | Wu, L., et al. 2018. Toxicol Appl Pharmacol. 359: 91-101. PMID: 30248416
- Resveratrol glucuronidation in vitro: potential implications of inhibition by probenecid. | Matin, B., et al. 2019. J Pharm Pharmacol. 71: 371-378. PMID: 30417385
- Inhibitory Effect of Probenecid on Osteoclast Formation via JNK, ROS and COX-2. | Cheng, MH. and Kim, SJ. 2020. Biomol Ther (Seoul). 28: 104-109. PMID: 31474032
- Pleiotropic effects of probenecid on three-dimensional cultures of prostate cancer cells. | Uwada, J., et al. 2021. Life Sci. 278: 119554. PMID: 33932444
- Probenecid: antibacterial action against Neisseria gonorrhoeae and interaction with benzylpenicillin. | Catlin, BW. 1984. Antimicrob Agents Chemother. 25: 676-82. PMID: 6430225
Inhibitor of:
βENaC, ABC-me, ABCB6, ABCF3, AE3, Amino acid-binding ABC transporter, AQP12, AQP12A, AQP6, ATPGD1, BGT-1, BOCT, C8orf5, CAT-4, connexin 33, Connexin 43, connexin 46, connexin 59, CSGlcA-T, CTL3, CYP4A12B, EG625716, EG665956, ficolin A, Gα 15, GlcAT-S, Glut9, GNGT2, GPR89B, HCP1 (SLC46A1), LPCAT1, MATE1, MFSD6L, MFSD9, MRP1, NPT1, OAT, OAT1, OAT2, OAT3, OAT6, OATP-J, Oatp5, Oct-2, Olfr340, Pannexin-1, Pannexin-2, Pannexin-3, PAPST2, PEPT1, PGT, PIPES, PQLC2, putrescine ABC transporter permease, rBAT, RCL, RFC-1, Sialin, SLC10A6, SLC10A7, SLC13A5, SLC15A solute carrier (SLC) group, SLC17A (solute carrier family 17), SLC17A2, SLC17A4, SLC22A11, SLC22A12, SLC22A14, SLC22A15, SLC22A23, Slc22a27, SLC22A9, SLC37A3, SLC5 (solute carrier family 5; SLC5A), Slco6c1, Slco6d1, SPNS3, Sulfiredoxin, SVCT3, T1R3, T2R05, T2R23, T2R26, T2R41, T2R8, TAS1R (taste receptor; GPCR), TMEM14A, TMEM87B, TRPT1, UGT1A3, UGT1A8, UGT2B, UGT2B1, UGT2B15, UGT2B17, UGT3A1, UGT3A2, UGT8, UGTREL1, UST1R, and Xg.Activator of:
ABCC11, ABCC12, ABCD4, CCDC109B, CD92, connexin 31.1, connexin 46, HEXA, MFSD3, MFSD5, MRP4, MRP6, NTPDase8, OATP-H, OATP-J, Oatp-Y, OCTN1, ORCTL2, P2X1, P2X6, PGP, SLC10A5, Slc22a27, SLC22A29, SLC26A11, SLC35E4, SLC45A4, SLC46A3, TMC4, VR1, and VRL-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Probenecid, 1 g | sc-202773 | 1 g | $27.00 | |||
Probenecid, 5 g | sc-202773A | 5 g | $38.00 | |||
Probenecid, 25 g | sc-202773B | 25 g | $98.00 | |||
Probenecid, 100 g | sc-202773C | 100 g | $272.00 |