[Pro⁹] Substance P (CAS 104486-69-3)

[Pro9] Substance P is a synthetic analog of the neuropeptide Substance P, engineered by substituting the ninth amino acid with proline to enhance its stability and modify its interaction with neurokinin-1 (NK1) receptors. This chemical is primarily used in research to probe the dynamics of pain perception and neurogenic inflammation. The mechanism of action for [Pro9] Substance P involves binding to NK1 receptors, which are G protein-coupled receptors predominantly found in the nervous system. Upon activation, these receptors stimulate signaling pathways that include the activation of phospholipase C, leading to increased production of inositol triphosphate and diacylglycerol. This cascade elevates intracellular calcium levels, which facilitates various physiological responses, including neuronal excitation and neurotransmitter release. In scientific studies, [Pro9] Substance P has been a valuable tool for investigating the role of NK1 receptors in pain pathways and inflammatory responses, helping to unravel complex neurochemical interactions and contributing to our understanding of neurotransmission without being directly linked to therapeutic applications. This peptide has thus been instrumental in advancing knowledge about receptor pharmacology and the modulation of inflammatory processes in the nervous system.