pro-MCH Antibody (1D1): sc-293231
- pro-MCH Antibody (1D1) is a mouse monoclonal IgG2a κ pro-MCH antibody provided at 100 µg/ml
- raised against a recombinant protein mapping to amino acids 1-165 representing full length pro-MCH of human origin
- recommended for detection of pro-MCH of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for pro-MCH Antibody (1D1). This work is in progress.
pro-MCH Antibody (1D1) is a mouse monoclonal IgG2a kappa light chain antibody that detects pro-MCH protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-pro-MCH antibody (1D1) is available as the non-conjugated form. Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic neuropeptide derived from a 165 amino acid pro-MCH precursor, which also includes a 144 amino acid mature MCH and two additional neuropeptides, glycine-glutamic acid (NGE) and glutamic acid-isoleucine (NEI). Primarily expressed in the hypothalamus, MCH plays a crucial role in regulating various physiological processes, including feeding behavior, aggression, anxiety, arousal, and reproductive function by influencing the release of luteinizing hormone (LH). The structure of MCH is particularly important as its cyclic nature allows for specific receptor interactions, which are essential for biological activity. The melanin-concentrating hormone receptor (MCHR, also known as SLC-1) is a glycosylated G protein-coupled receptor that mediates MCH effects through Gαi and/or Gαq signaling pathways. MCHR is expressed in several brain regions, including the cerebral cortex, amygdala, thalamus, and hypothalamus, and has been implicated in stimulating leptin expression and secretion in adipocytes. This suggests that both MCH and MCHR may serve as potential targets for therapeutic strategies aimed at modulating obesity and related metabolic disorders.
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pro-MCH Antibody (1D1) References:
- (D-(p-benzoylphenylalanine)13, tyrosine19)-melanin-concentrating hormone, a potent analogue for MCH receptor crosslinking. | Drozdz, R., et al. 1999. J Pept Sci. 5: 234-42. PMID: 10363906
- Molecular characterization of the melanin-concentrating-hormone receptor. | Saito, Y., et al. 1999. Nature. 400: 265-9. PMID: 10421368
- The influence of gonadal steroids on pre-pro melanin-concentrating hormone mRNA in female rats. | Murray, JF., et al. 2000. J Neuroendocrinol. 12: 53-9. PMID: 10692143
- Melanin-concentrating hormone, melanocortin receptors and regulation of luteinizing hormone release. | Murray, JF., et al. 2000. J Neuroendocrinol. 12: 217-23. PMID: 10718917
- The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat. | Hervieu, GJ., et al. 2000. Eur J Neurosci. 12: 1194-216. PMID: 10762350
- Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes. | Bradley, RL., et al. 2000. Diabetes. 49: 1073-7. PMID: 10909960
- The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways. | Hawes, BE., et al. 2000. Endocrinology. 141: 4524-32. PMID: 11108264
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
pro-MCH Antibody (1D1) | sc-293231 | 100 µg/ml | $316.00 |