Anti-PRL-1/2/3 Antibody (D-6) is a mouse monoclonal IgG1 (kappa light chain) PRL-1/2/3 antibody provided at 200 µg/ml
specific for an epitope mapping between amino acids 121-149 near the C-terminus of PRL-1 of human origin
PRL-1/2/3 Antibody (D-6) is recommended for detection of PRL-1, PRL-2 and PRL-3 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
Anti-PRL-1/2/3 Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PRL-1/2/3 (D-6): sc-271879.
At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PRL-1/2/3 Antibody (D-6). This work is in progress.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
PRL-1/2/3 Antibody (D-6) is a high quality monoclonal PRL-1/2/3 antibody (also designated PRL-1/2/3 antibody) suitable for the detection of the PRL-1/2/3 protein of mouse, rat and human origin. PRL-1/2/3 Antibody (D-6) is available as both the non-conjugated anti-PRL-1/2/3 antibody form, as well as multiple conjugated forms of anti-PRL-1/2/3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Protein tyrosine phosphatases (PTPs) play a role in regulating diverse cellular processes. They form a small class of prenylated protein phosphatases called PRL proteins characterized by a C-terminal consensus sequence for prenylation. PRL-1, also designated Protein tyrosine phosphatase type IVA protein 1 (PTP4A1), is a unique nuclear PTP that is induced in regenerating liver and mitogen-stimulated cells. It is primarily expressed in spleen, bone marrow, thymus, lymph nodes, T lymphocytes and tonsil and is overexpressed in tumor cell lines. PRL-2 (Protein tyrosine phosphatase type IVA protein 2, or PTP4A2) is ubiquitously expressed with highest levels in heart, skeletal muscle and thymus but is also overexpressed in prostate tumor tissue. PPRL-2 is stimulates progression from G1 into S phase during mitosis and promotes tumors. PRL-3, also known as Protein Tyrosine Phosphatase Type IVA, member 3 (PTP4A3) is expressed in heart and skeletal muscle as well as epithelial cells of the small intestine and associates with the cell plasma membrane. Over expression of PRL-3 inhibits angiotensin-II induced cell calcium mobilization and promotes cell growth. PRL-3 is important for colorectal cancer metastasis and may serve as a new therapeutic target for this condition.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences