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Prilocaine hydrochloride (CAS 1786-81-8)

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Alternate Names:
N-(2-Methylphenyl)-2-(propylamino)propanamide hydrochloride
Application:
Prilocaine hydrochloride is a chemical with pharmacological properties similar to those of lidocaine
CAS Number:
1786-81-8
Purity:
≥99%
Molecular Weight:
256.77
Molecular Formula:
C13H20N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Prilocaine hydrochloride is a local anesthetic that functions by blocking the voltage-gated sodium channels in the neuronal cell membrane. This blockade prevents the generation and conduction of nerve impulses, leading to a reversible loss of sensation in the targeted area. Prilocaine hydrochloride inhibits the ionic fluxes required for the initiation and conduction of impulses, thereby interfering with the transmission of pain signals. Prilocaine Hydrochloride′s mechanism of action involves binding to the sodium channels in the nerve membrane, which stabilizes the neuronal membrane and inhibits the initiation and conduction of nerve impulses. By interfering with the transmission of pain signals, prilocaine hydrochloride effectively produces a local anesthetic effect, making it suitable for various experimental applications that require temporary loss of sensation in specific areas.


Prilocaine hydrochloride (CAS 1786-81-8) References

  1. Cardiovascular responses to intraosseous injections of prilocaine containing vasoconstrictors.  |  Lilienthal, B. 1976. Oral Surg Oral Med Oral Pathol. 42: 552-8. PMID: 1068411
  2. NMR characterisation and transdermal drug delivery potential of microemulsion systems.  |  Kreilgaard, M., et al. 2000. J Control Release. 69: 421-33. PMID: 11102682
  3. Stability-indicating HPLC assays for the determination of prilocaine and procaine drug combinations.  |  Storms, ML. and Stewart, JT. 2002. J Pharm Biomed Anal. 30: 49-58. PMID: 12151064
  4. Verification of protector effect of the norepinephrine and felypressin upon the cardiovascular system under action of the lidocaine hydrochloride and prilocaine hydrochloride in anesthetized rats.  |  Araújo, LD., et al. 2002. Pharmacol Res. 46: 107-11. PMID: 12220948
  5. Analysis of the antimicrobial activity of local anaesthetics used for dental analgesia.  |  Pelz, K., et al. 2008. J Med Microbiol. 57: 88-94. PMID: 18065672
  6. Prilocaine hydrochloride protects zebrafish from lethal effects of ionizing radiation: role of hematopoietic cell expansion.  |  Dimri, M., et al. 2015. Tokai J Exp Clin Med. 40: 8-15. PMID: 25843444
  7. The effect of electrostatic interactions on the formation of pharmaceutical eutectics.  |  Wojnarowska, Z., et al. 2018. Phys Chem Chem Phys. 20: 27361-27367. PMID: 30357184
  8. Effect of electrostatic interactions on the relaxation dynamics of pharmaceutical eutectics.  |  Wojnarowska, Z., et al. 2019. Eur J Pharm Sci. 134: 93-101. PMID: 30986473
  9. Increase in pulse pressure on administration of a dental local anesthetic solution, prilocaine hydrochloride with felypressin in male diabetic patients with coronary heart disease.  |  Kubota, K., et al. 2020. Clin Oral Investig. 24: 239-246. PMID: 31079247
  10. A new all purpose anesthetic prilocaine hydrochloride 4 per cent with epinephrine 1:200.000.  |  Andrews, AG. 1968. R Can Dent Corps Q. 9: 5-12. PMID: 5246406
  11. The use of prilocaine hydrochloride (Citanest) for epidural analgesia in obstetrics.  |  Poppers, PJ. and Finster, M. 1968. Anesthesiology. 29: 1134-8. PMID: 5726750
  12. Evaluation of a local anesthetic agent. Prilocaine hydrochloride (Citanest).  |  . 1967. JAMA. 199: 837. PMID: 6071298
  13. Acute toxic methemoglobinemia following dental analgesia.  |  Ludwig, SC. 1981. Ann Emerg Med. 10: 265-6. PMID: 7224278

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Prilocaine hydrochloride, 1 g

sc-253317
1 g
$57.00

Prilocaine hydrochloride, 5 g

sc-253317A
5 g
$189.00