Molecular structure of Previtamin D3, CAS Number: 1173-13-3
Previtamin D3 (CAS 1173-13-3)
Alternate Names:
Precalciferol3; Precholecalciferol; Previtamin D
CAS Number:
1173-13-3
Molecular Weight:
384.64
Molecular Formula:
C27H44O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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When sunlight interacts with 7-dehydrocholesterol in the skin, it leads to the production of previtamin D3, which is later converted to vitamin D3 in the liver and kidneys. Vitamin D3 plays a significant role in biochemical processes, particularly in regulating calcium and phosphate balance within the body. After its conversion, vitamin D3 is carried through the bloodstream to specific cells, where it binds to the vitamin D receptor (VDR). Activation of the VDR then initiates the vitamin D response element (VDRE), which prompts the expression of genes responsible for maintaining calcium and phosphate homeostasis.
Previtamin D3 (CAS 1173-13-3) References
- An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D3 and previtamin D3. | Chen, TC., et al. 2000. J Nutr Biochem. 11: 267-72. PMID: 10876100
- Previtamin D3 with a trans-fused decalin CD-ring has pronounced genomic activity. | Verlinden, L., et al. 2003. J Biol Chem. 278: 35476-82. PMID: 12829710
- Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. | Holick, MF. 2004. Am J Clin Nutr. 80: 1678S-88S. PMID: 15585788
- Sunlight and Vitamin D: A global perspective for health. | Wacker, M. and Holick, MF. 2013. Dermatoendocrinol. 5: 51-108. PMID: 24494042
- Skin as the site of vitamin D synthesis and target tissue for 1,25-dihydroxyvitamin D3. Use of calcitriol (1,25-dihydroxyvitamin D3) for treatment of psoriasis. | Holick, MF., et al. 1987. Arch Dermatol. 123: 1677-1683a. PMID: 2825606
- Environmental determinants of previtamin D synthesis in the United Arab Emirates. | Buckley, AJ., et al. 2017. Dermatoendocrinol. 9: e1267079. PMID: 29657665
- Differential Thermal Isomerization: Its Role in the Analysis of Vitamin D3 in Foods. | Gill, BD., et al. 2020. J AOAC Int. 103: 563-569. PMID: 33241273
- Photosynthesis of previtamin D3 in human skin and the physiologic consequences. | Holick, MF., et al. 1980. Science. 210: 203-5. PMID: 6251551
- The cutaneous photosynthesis of previtamin D3: a unique photoendocrine system. | Holick, MF. 1981. J Invest Dermatol. 77: 51-8. PMID: 6265564
- Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin. | MacLaughlin, JA., et al. 1982. Science. 216: 1001-3. PMID: 6281884
- Kinetic and thermodynamic studies of the conversion of previtamin D3 to vitamin D3 in human skin. | Tian, XQ., et al. 1993. J Biol Chem. 268: 14888-92. PMID: 8392061
- Noncalcemic actions of 1,25-dihydroxyvitamin D3 and clinical applications. | Holick, MF. 1995. Bone. 17: 107S-111S. PMID: 8579891
- A liposomal model that mimics the cutaneous production of vitamin D3. Studies of the mechanism of the membrane-enhanced thermal isomerization of previtamin D3 to vitamin D3. | Tian, XQ. and Holick, MF. 1999. J Biol Chem. 274: 4174-9. PMID: 9933613
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Previtamin D3, 1 mg | sc-476627 | 1 mg | $322.00 |