Prestin Antibody (1F4): sc-293212

Prestin Antibody (1F4) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Prestin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Prestin antibody (1F4) is available as a non-conjugated format. Prestin, also known as SLC26A5, is a crucial transmembrane protein located in the outer hair cells of the cochlea, where Prestin plays a vital role in the auditory system. Prestin (1F4) antibody recognizes a protein responsible for the remarkable ability of outer hair cells to change their length in response to sound stimuli, which is essential for the sensitivity and frequency selectivity of mammalian hearing. Prestin functions as a direct voltage-to-force converter, utilizing cytoplasmic anions as extrinsic voltage sensors, allowing Prestin to operate at microsecond rates. The presence of intracellular anions, such as chloride and bicarbonate, is critical for Prestin′s role as the motor molecule of outer hair cells, facilitating sound amplification by mediating changes in cell length in response to variations in membrane potential. Notably, the voltage sensitivity of Prestin is significantly influenced by temperature, highlighting Prestin′s intricate relationship with the physiological conditions of the cochlea.

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Prestin Antibody (1F4) References:

1. Temperature dependence of non-linear capacitance in human embryonic kidney cells transfected with prestin, the outer hair cell motor protein.  |  Meltzer, J. and Santos-Sacchi, J. 2001. Neurosci Lett. 313: 141-4. PMID: 11682147
2. Prestin, a new type of motor protein.  |  Dallos, P. and Fakler, B. 2002. Nat Rev Mol Cell Biol. 3: 104-11. PMID: 11836512
3. Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin.  |  Weber, T., et al. 2002. Proc Natl Acad Sci U S A. 99: 2901-6. PMID: 11867734
4. Prestin, the motor protein of outer hair cells.  |  Zheng, J., et al. 2002. Audiol Neurootol. 7: 9-12. PMID: 11914518
5. Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review.  |  Iliadou, E., et al. 2021. Ear Hear. 42: 1127-1136. PMID: 33900207
6. Prestin amplifies cardiac motor functions.  |  Zhang, XD., et al. 2021. Cell Rep. 35: 109097. PMID: 33951436
7. Prestin and electromotility may serve multiple roles in cochlear outer hair cells.  |  Zheng, J., et al. 2022. Hear Res. 423: 108428. PMID: 34987016
8. Progress in understanding the structural mechanism underlying prestin's electromotile activity.  |  Lenz, D. and Oliver, D. 2022. Hear Res. 423: 108423. PMID: 34987017
9. Blood prestin levels in COVID-19 patients.  |  Turan, M., et al. 2023. J Chin Med Assoc. 86: 571-576. PMID: 36967481
10. Elevator-like movements of prestin mediate outer hair cell electromotility.  |  Kuwabara, MF., et al. 2023. Nat Commun. 14: 7145. PMID: 37932294
11. Folding of prestin's anion-binding site and the mechanism of outer hair cell electromotility.  |  Lin, X., et al. 2023. Elife. 12: PMID: 38054956
12. Functional Studies of Deafness-Associated Pendrin and Prestin Variants.  |  Takahashi, S., et al. 2024. Int J Mol Sci. 25: PMID: 38474007