Prednisone-d8 (CAS 53-03-2 unlabeled)
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Prednisone-d8 is a deuterated analog of prednisone. This stable isotope-labeled compound is primarily used as an internal standard in mass spectrometry-based assays to quantify prednisone levels in biological samples. In analytical research, the incorporation of deuterium increases the molecular weight of prednisone-d8 slightly, allowing it to be distinguished from non-deuterated prednisone even when they co-elute in chromatographic separations. Scientists rely on this isotopic labeling to reduce analytical variability and improve the accuracy of their measurements. Moreover, prednisone-d8 is utilized in metabolic studies to track the disposition and biotransformation of prednisone in the body, providing deeper insights into its kinetics.
Prednisone-d8 (CAS 53-03-2 unlabeled) References
- Physiologically Based Pharmacokinetic Modeling Involving Nonlinear Plasma and Tissue Binding: Application to Prednisolone and Prednisone in Rats. | Li, X., et al. 2020. J Pharmacol Exp Ther. 375: 385-396. PMID: 32883831
- Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids. | Wintzinger, M., et al. 2022. Mol Metab. 62: 101528. PMID: 35717025
- Simultaneous Measurement of Cortisol, Cortisone, Dexamethasone and Additional Exogenous Corticosteroids by Rapid and Sensitive LC-MS/MS Analysis. | Ponzetto, F., et al. 2022. Molecules. 28: PMID: 36615443
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prednisone-d8, 0.25 mg | sc-477081 | 0.25 mg | $398.00 |