Molecular structure of Prazosin-d8, CAS Number: 1006717-55-0
Prazosin-d8 (CAS 1006717-55-0)
Application:
Prazosin-d8 is a deuterium-labeled analogue of Prazosin
CAS Number:
1006717-55-0
Molecular Weight:
391.45
Molecular Formula:
C19H13D8N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Prazosin-d8 is a deuterium-labeled analog of Prazosin (sc-280021). Prazosin is an adrenergic α, α2B-adrenoceptor and a potent melatonin MT3 receptor antagonist. A study investigated the putative inhibitory effect of prazosin on changes evoked by a NMDA receptor antagonist, MK-801 within the Syrian hamster hypothalamus. This study reported that prazosin was a potent and selective α1-adrenoceptor antagonist and was able to supress MK-801 evoked changes, without affecting basal dopamine release in nucleus accumbens. Additionally, in this study prazosin was reported to block MK-801 evoked locomotor stimulation with little affect on basal locomotor activity.
Prazosin-d8 (CAS 1006717-55-0) References
- Characterization of 2-[125I]iodomelatonin binding sites in Syrian hamster peripheral organs. | Paul, P., et al. 1999. J Pharmacol Exp Ther. 290: 334-40. PMID: 10381796
- Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus. | Pickering, DS. and Niles, LP. 1990. Eur J Pharmacol. 175: 71-7. PMID: 2157597
- Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens. | Mathé, JM., et al. 1996. Eur J Pharmacol. 309: 1-11. PMID: 8864686
Inhibitor of:
alpha2B-AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prazosin-d8, 1 mg | sc-219639 | 1 mg | $500.00 |