Prazosin is an adrenergic α, α2B-adrenoceptor and a potent melatonin MT3 receptor antagonist. A study investigated the putative inhibitory effect of prazosin on changes evoked by a NMDA receptor antagonist, MK-801 within the Syrian hamster hypothalamus in vitro. This study reported that prazosin was a potent and selective α1-adrenoceptor antagonist and was able to supress MK-801 evoked changes, without affecting basal dopamine release in nucleus accumbens in vitro. Additionally, in this study prazosin was reported to block MK-801 evoked locomotor stimulation with little affect on basal locomotor activity in vitro.
Also offered as a salt: Prazosin hydrochloride (sc-204858.)
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See how others have used Prazosin (CAS 19216-56-9). Click on the entry to view the PubMed entry .
PMID: # 31111492 Yue, L.|Qin, X.|Liu, X.|Wang, Z.|Dong, Y.|Chen, Y.|Cao, J.| et al. 2019. Photochem. Photobiol.
PMID: # 28660299 Guo, Q.|Wang, Z.|Dong, Y.|Cao, J.|Chen, Y.| et al. 2017. Cell Tissue Res. 369: 555-565.
PMID: # 27128575 Li, S.|Cao, J.|Wang, Z.|Dong, Y.|Wang, W.|Chen, Y.| et al. 2016. Photochem. Photobiol. 92: 595-603.
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