Prazosin CAS: 19216-56-9
MF: C19H21N5O4
MW: 383.41
A useful α1 and α2B-adrenoceptor antagonist.

Prazosin (CAS 19216-56-9)

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Application: Prazosin is a useful α1 and α2B-adrenoceptor antagonist
CAS Number: 19216-56-9
Molecular Weight: 383.41
Molecular Formula: C19H21N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Prazosin is an adrenergic α, α2B-adrenoceptor and a potent melatonin MT3 receptor antagonist. A study investigated the putative inhibitory effect of prazosin on changes evoked by a NMDA receptor antagonist, MK-801 within the Syrian hamster hypothalamus in vitro. This study reported that prazosin was a potent and selective α1-adrenoceptor antagonist and was able to supress MK-801 evoked changes, without affecting basal dopamine release in nucleus accumbens in vitro. Additionally, in this study prazosin was reported to block MK-801 evoked locomotor stimulation with little affect on basal locomotor activity in vitro.
Also offered as a salt: Prazosin hydrochloride (sc-204858.)


References

1. Pickering, D.S. and Niles, L.P. 1990. Eur. J. Pharmacol. 175: 71-77. PMID: 2157597
2. Mathé, J.M., et al. 1996. Eur. J. Pharmacol. 309: 1-11. PMID: 8864686
3. Paul, P., et al. 1999. J. Pharmacol. Exp. Ther. 290: 334-340. PMID: 10381796

Physical State :
Solid
Storage :
Store at room temperature
Melting Point :
279-285° C
Boiling Point :
638.4° C at 760 mmHg
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4893
SMILES :
COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC

Download SDS (MSDS)

Certificate of Analysis

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Prazosin (CAS 19216-56-9)  Product Citations

See how others have used Prazosin (CAS 19216-56-9). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 31111492  Yue, L.|Qin, X.|Liu, X.|Wang, Z.|Dong, Y.|Chen, Y.|Cao, J.| et al. 2019. Photochem. Photobiol.

PMID: # 28660299  Guo, Q.|Wang, Z.|Dong, Y.|Cao, J.|Chen, Y.| et al. 2017. Cell Tissue Res. 369: 555-565.

PMID: # 27128575  Li, S.|Cao, J.|Wang, Z.|Dong, Y.|Wang, W.|Chen, Y.| et al. 2016. Photochem. Photobiol. 92: 595-603.

Citations 1 to 3 of 3 total

Is this product soluble in DMSO?

Asked by: hawkeye11
Thank you for your question. Prazosin, sc-280021, is soluble in DMSO. Please follow this linked protocol: http://www.medchemexpress.com/prazosin.html.
Answered by: TechService7
Date published: 2018-07-06
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