Pramlintide Acetate (CAS 196078-30-5)
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Pramlintide Acetate, a synthetic analog of amylin, functions by engaging specific receptors in the brain to initiate a cascade of metabolic reactions. As a mimic of the naturally occurring pancreatic hormone, it effectively diminishes hepatic glucose production while promoting enhanced glucose uptake at the cellular level. This analogue specifically mimics the action of amylin by participating in the complex coordination of physiological responses that manage glucose and nutrient absorption. In the context of scientific research, Pramlintide Acetate Hydrate′s mimicry of amylin′s functions provides a tool for dissecting the hormonal regulation of glucose homeostasis. It facilitates investigations into the interplay between hormones that influence metabolic pathways, offering insights into how the body maintains energy balance.
Pramlintide Acetate (CAS 196078-30-5) References
- A biophysical characterization of the peptide drug pramlintide (AC137) using empirical phase diagrams. | Nonoyama, A., et al. 2008. J Pharm Sci. 97: 2552-67. PMID: 17879973
- Implications of amylin receptor agonism: integrated neurohormonal mechanisms and therapeutic applications. | Roth, JD., et al. 2009. Arch Neurol. 66: 306-10. PMID: 19273748
- Amylin analogues in the treatment of diabetes mellitus: medicinal chemistry and structural basis of its function. | Adeghate, E. and Kalász, H. 2011. Open Med Chem J. 5: 78-81. PMID: 21966328
- Study of forced degradation behavior of pramlintide acetate by HPLC and LC-MS. | Yuan, Y., et al. 2018. J Food Drug Anal. 26: 409-415. PMID: 29389581
- Physico-chemical properties of co-formulated fast-acting insulin with pramlintide. | da Silva, DC. and Lima, LMTR. 2018. Int J Pharm. 547: 621-629. PMID: 29928940
- Physico-chemical stability of co-formulation of PEGylated human amylin with insulin. | Sinésia, C., et al. 2019. Pharm Dev Technol. 24: 975-981. PMID: 31124388
- Effects of pramlintide on energy intake and food preference in rats given a choice diet. | Kern, KA., et al. 2021. Physiol Behav. 240: 113541. PMID: 34332974
- Injectable Biodegradable Silica Depot: Two Months of Sustained Release of the Blood Glucose Lowering Peptide, Pramlintide. | Tyagi, P., et al. 2022. Pharmaceutics. 14: PMID: 35335929
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pramlintide Acetate, 2.5 mg | sc-476040 | 2.5 mg | $408.00 | |||
Pramlintide Acetate, 25 mg | sc-476040A | 25 mg | $2866.00 |