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Pralidoxime Chloride (CAS 51-15-0)

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Alternate Names:
Pyridine-2-aldoxime methochloride; 2-PAM chloride
CAS Number:
51-15-0
Purity:
≥99%
Molecular Weight:
172.61
Molecular Formula:
C7H9ClN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Pralidoxime chloride functions as a cholinesterase reactivator in experimental applications. Its mechanism of action involves the reactivation of acetylcholinesterase, an enzyme that is for the proper functioning of the nervous system. When certain organophosphate compounds inhibit acetylcholinesterase, pralidoxime chloride can bind to the inhibited enzyme and restore its activity, thereby reversing the toxic effects of the organophosphate compound. This reactivation occurs through a process known as nucleophilic substitution, where pralidoxime chloride displaces the organophosphate compound from the active site of the enzyme. By restoring the activity of acetylcholinesterase, pralidoxime chloride plays a functional role in experimental studies aimed at understanding the mechanisms of organophosphate toxicity and developing potential interventions. Its ability to reactivate acetylcholinesterase may be valuable for investigating the molecular and cellular effects of organophosphate compounds on the nervous system.


Pralidoxime Chloride (CAS 51-15-0) References

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  2. Repeated pulse intramuscular injection of pralidoxime chloride in severe acute organophosphorus pesticide poisoning.  |  Tang, X., et al. 2013. Am J Emerg Med. 31: 946-9. PMID: 23680326
  3. Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides.  |  Lucyk, S., et al. 2014. Toxicol Sci. 138: 482. PMID: 24385419
  4. Protection by a transdermal patch containing eserine and pralidoxime chloride for prophylaxis against (±)-Anatoxin A poisoning in rats.  |  Banerjee, S., et al. 2014. Eur J Pharm Sci. 56: 28-36. PMID: 24530375
  5. Pharmacokinetic and biodistribution study of eserine and pralidoxime chloride in rabbits following a single application of a transdermal patch.  |  Banerjee, S., et al. 2016. Eur J Drug Metab Pharmacokinet. 41: 219-30. PMID: 25547639
  6. Atropine absorption after intramuscular administration with 2-pralidoxime chloride by two automatic injector devices.  |  Friedl, KE., et al. 1989. J Pharm Sci. 78: 728-31. PMID: 2585264
  7. Intramuscular versus Intraosseous Delivery of Nerve Agent Antidote Pralidoxime Chloride in Swine.  |  Uwaydah, NI., et al. 2016. Prehosp Emerg Care. 20: 485-92. PMID: 27158860
  8. Pralidoxime chloride stability-indicating assay and analysis of solution samples stored at room temperature for ten years.  |  Schroeder, AC., et al. 1989. J Pharm Sci. 78: 132-6. PMID: 2715935
  9. Exploring pralidoxime chloride as a universal electrochemical probe for organophosphorus pesticides detection.  |  Zheng, Q., et al. 2017. Anal Chim Acta. 982: 78-83. PMID: 28734368
  10. Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents.  |  Zhao, D., et al. 2022. Inorg Chem. 61: 1512-1520. PMID: 34969248
  11. Cation-Exchangeable Pralidoxime Chloride@bio-MOF-1 as a Treatment for Nerve Agent Poisoning and Sulfur Mustard Skin Poisoning in Animals.  |  Yang, Y., et al. 2022. ACS Omega. 7: 30720-30729. PMID: 36092617
  12. Degradation pathway of pralidoxime chloride in concentrated acidic solution.  |  Fyhr, P., et al. 1986. J Pharm Sci. 75: 608-11. PMID: 3735107
  13. Pharmacokinetics of pralidoxime chloride in the rat.  |  Green, MD., et al. 1986. Life Sci. 39: 2263-9. PMID: 3784779
  14. Effects of atropine sulfate and pralidoxime chloride on visual, physiological, performance, subjective, and cognitive variables in man: a review.  |  Headley, DB. 1982. Mil Med. 147: 122-32. PMID: 6806696
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Pralidoxime Chloride, 1 g

sc-212578
1 g
$140.00