Pr-Set7 Antibody (D-4): sc-515433

Pr-Set7 Antibody (D-4) is a mouse monoclonal IgG3 antibody that detects Pr-Set7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pr-Set7, also known as SET8, is a crucial enzyme involved in the regulation of histone methylation, specifically targeting histone H4 at lysine 20. This post-translational modification is essential for the establishment and maintenance of heterochromatin, which plays a significant role in gene expression regulation and chromatin structure. anti-Pr-Set7 antibody (D-4) recognizes the monomethylation of H4 at Lys 20, which is vital for cell-cycle-dependent transcriptional silencing and mitotic regulation in metazoans, ensuring proper cellular function and division. The stability of the methylation mark, even in the absence of Pr-Set7, highlights its importance in maintaining chromatin integrity and gene expression patterns. Pr-Set7 (D-4) antibody serves as an invaluable tool for researchers studying epigenetic regulation and chromatin dynamics, providing insights into the mechanisms underlying gene expression and cellular differentiation.

The preferred Pr-Set7 antibody is Pr-Set7 Antibody (D-11): sc-377034.