Molecular structure of PQ401, CAS Number: 196868-63-0
PQ401 (CAS 196868-63-0)
Application:
PQ401 is an inhibitor of IGF-1R autophosphorylation
CAS Number:
196868-63-0
Purity:
≥98%
Molecular Weight:
341.8
Molecular Formula:
C18H16ClN3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PQ401 is a compound used in the study of insulin-like growth factor 1 receptor (IGF-1R) signaling pathways. It acts as an inhibitor of IGF-1R autophosphorylation, impeding the activation and subsequent signaling that is mediated by this receptor tyrosine kinase. Research with PQ401 is focused on understanding the role of IGF-1R in cellular proliferation, differentiation, and apoptosis. By blocking IGF-1R signaling, PQ401 helps in dissecting the contributions of this pathway to the development and progression of cancers, as the IGF-1R is known to be overexpressed in various tumor types. This inhibitor is also valuable in the study of metabolic disorders, given the importance of IGF-1R in growth and metabolism regulation.
PQ401 (CAS 196868-63-0) References
- Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. | Gable, KL., et al. 2006. Mol Cancer Ther. 5: 1079-86. PMID: 16648580
- Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition. | Sivakumar, R., et al. 2009. Int J Oncol. 34: 329-38. PMID: 19148466
- Bone marrow cell-induced protection of the human myocardium: characterization and mechanism of action. | Lai, VK., et al. 2009. J Thorac Cardiovasc Surg. 138: 1400-08.e1. PMID: 19692000
- Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. | Sanchez-Alavez, M., et al. 2011. J Biol Chem. 286: 14983-90. PMID: 21330367
- The effects of type 1 IGF receptor inhibition in a mouse model of diabetic kidney disease. | Troib, A., et al. 2011. Growth Horm IGF Res. 21: 285-91. PMID: 21865067
- Activation of the insulin-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells. | Jameson, MJ., et al. 2011. Mol Cancer Ther. 10: 2124-34. PMID: 21878657
- Progranulin compensates for blocked IGF-1 signaling to promote myotube hypertrophy in C2C12 myoblasts via the PI3K/Akt/mTOR pathway. | Hu, SY., et al. 2012. FEBS Lett. 586: 3485-92. PMID: 22967900
- PQ401, an IGF-1R inhibitor, induces apoptosis and inhibits growth, proliferation and migration of glioma cells. | Zhou, X., et al. 2016. J Chemother. 28: 44-9. PMID: 25971682
- IGF1 regulates RUNX1 expression via IRS1/2: Implications for antler chondrocyte differentiation. | Yang, ZQ., et al. 2017. Cell Cycle. 16: 522-532. PMID: 28055425
- The therapeutic effects of blocking IGF-R1 on mice model of skin cancer. | Alyoussef, A. 2021. J Dermatolog Treat. 32: 803-811. PMID: 31868059
- IGF-1R inhibitor PQ401 inhibits osteosarcoma cell proliferation, migration and colony formation. | Qi, B., et al. 2019. Int J Clin Exp Pathol. 12: 1589-1598. PMID: 31933976
- The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus. | Kim, W., et al. 2020. mBio. 11: PMID: 32605985
Inhibitor of:
A2LD1, BZW1, IGF-IA, IGF-IB, IGF-II, IGF-IIR, IGF-IR, IGFBP3, IGFBP4, IGFBPL1, IGFL2, IGRP, INSL4, Insulin II, Mast Cell Protease 9, Rga1, and TRC8.Activator of:
ASPHD1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PQ401, 10 mg | sc-221738 | 10 mg | $146.00 |