Molecular structure of (±)-PPCC oxalate, CAS Number: 932736-90-8
(±)-PPCC oxalate (CAS 932736-90-8)
Alternate Names:
(S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic acid methyl ester
Application:
(±)-PPCC oxalate is a selective &sigma receptor ligand with a high affinity for σ1
CAS Number:
932736-90-8
Molecular Weight:
469.53
Molecular Formula:
C24H29NO3•C2H2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)-PPCC oxalate is a selective sigma (σ) receptor ligand which is noted to exhibit high affinity for σ1 and also binds at σ2 sites. Reported selectivity over a range of receptors such as muscarinic and dopaminergic receptors as well as SERT and DAT.
(±)-PPCC oxalate (CAS 932736-90-8) References
- Novel sigma receptor ligands: synthesis and biological profile. | Prezzavento, O., et al. 2007. J Med Chem. 50: 951-61. PMID: 17328523
- A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. | Prezzavento, O., et al. 2008. Life Sci. 82: 549-53. PMID: 18261749
- Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. | Antonini, V., et al. 2009. J Neurochem. 109: 744-54. PMID: 19245662
- The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. | Malik, M., et al. 2015. Br J Pharmacol. 172: 2519-31. PMID: 25573298
- Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. | Rodríguez-Muñoz, M., et al. 2018. Oncotarget. 9: 23373-23389. PMID: 29805740
- Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice. | Sánchez-Blázquez, P., et al. 2018. Int J Neuropsychopharmacol. 21: 938-948. PMID: 29860313
- αN-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers. | Garzón-Niño, J., et al. 2022. Int J Mol Sci. 24: PMID: 36614024
Activator of:
Sigma Receptor.Substrate of:
Sigma Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-PPCC oxalate, 10 mg | sc-358806 | 10 mg | $159.00 | |||
(±)-PPCC oxalate, 50 mg | sc-358806A | 50 mg | $665.00 |