PPARβ Antibody (F-10): sc-74517

PPARβ Antibody (F-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects PPARβ protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PPARβ (F-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The peroxisome proliferator-activated receptor beta (PPARβ), also known as PPARδ, is a member of the nuclear hormone receptor superfamily and plays a crucial role in regulating gene expression related to lipid metabolism, inflammation, and cellular differentiation. PPARβ forms heterodimers with retinoid X receptors (RXRs) and binds to specific DNA sequences known as PPAR-response elements (PPREs), which is essential for the transcriptional regulation of target genes. This interaction is particularly important in tissues such as skeletal muscle and adipose tissue, where PPARβ influences fatty acid oxidation and energy homeostasis. PPARβ is involved in various physiological processes, including wound healing and the modulation of inflammatory responses, making PPARβ a significant target for therapeutic interventions in metabolic disorders and cardiovascular diseases. Anti-PPARβ antibody (F-10) versatility in multiple applications allows researchers to explore the diverse functions of PPARβ in various biological contexts.

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PPARβ Antibody (F-10) References:

1. Guiding ligands to nuclear receptors.  |  Michalik, L. and Wahli, W. 2007. Cell. 129: 649-51. PMID: 17512397
2. Physiological functions of peroxisome proliferator-activated receptor β.  |  Neels, JG. and Grimaldi, PA. 2014. Physiol Rev. 94: 795-858. PMID: 24987006
3. Unraveling the Effects of PPARβ/δ on Insulin Resistance and Cardiovascular Disease.  |  Vázquez-Carrera, M. 2016. Trends Endocrinol Metab. 27: 319-334. PMID: 27005447
4. Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer.  |  Peters, JM., et al. 2019. Mol Carcinog. 58: 1612-1622. PMID: 31062422
5. Revealing the role of peroxisome proliferator-activated receptor β/δ in nonalcoholic fatty liver disease.  |  Zarei, M., et al. 2021. Metabolism. 114: 154342. PMID: 32810487
6. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.  |  Braissant, O., et al. 1996. Endocrinology. 137: 354-66. PMID: 8536636
7. Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm.  |  Lemberger, T., et al. 1996. J Biol Chem. 271: 1764-9. PMID: 8576180
8. Differential activation of adipogenesis by multiple PPAR isoforms.  |  Brun, RP., et al. 1996. Genes Dev. 10: 974-84. PMID: 8608944
9. Regulation of peroxisome proliferator-activated receptor-alpha mRNA in rat liver.  |  Sterchele, PF., et al. 1996. Arch Biochem Biophys. 326: 281-9. PMID: 8611035
10. The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling.  |  Miyata, KS., et al. 1996. J Biol Chem. 271: 9189-92. PMID: 8621574
11. Crosstalk between the thyroid hormone and peroxisome proliferator-activated receptors in regulating peroxisome proliferator-responsive genes.  |  Hunter, J., et al. 1996. Mol Cell Endocrinol. 116: 213-21. PMID: 8647322
12. Expression of the peroxisome proliferator-activated receptor (PPAR) in the mouse colonic mucosa.  |  Mansén, A., et al. 1996. Biochem Biophys Res Commun. 222: 844-51. PMID: 8651933

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PPARβ Antibody (F-10) has 54 citations in a variety of scientific publications.

Primary antibodies like Anti-PPARβ Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PPARβ Antibody (F-10) Specifications

Alternate Product Name: PPAR Delta

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-75

Epitope Target: PPARβ

Epitope Species: mouse

Product Reactivity/Detection: PPARβ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 54 citations in various scientific publications

Available Conjugates/Forms for PPARβ Antibody (F-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent