Molecular structure of PPAHV, CAS Number: 175796-50-6
PPAHV (CAS 175796-50-6)
Alternate Names:
Phorbol 12-phenylacetate 13-acetate 20-homovanillate
Application:
PPAHV is non-pungent resiniferatoxin-type phorboid vanilloid and agonist
CAS Number:
175796-50-6
Purity:
≥98%
Molecular Weight:
688.8
Molecular Formula:
C39H44O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PPAHV is a chemical that functions as a potent inhibitor of a specific enzyme involved in cellular signaling pathways. It exerts its mechanism of action by binding to the active site of the enzyme, thereby preventing its normal function and disrupting downstream signaling cascades. This disruption ultimately leads to the inhibition of certain cellular processes. PPAHV may act to modulate the expression of certain genes involved in cell proliferation and differentiation, further expanding its potential applications in experimental applications. Its precise mechanism of action at the molecular level may be useful for investigating the regulatory networks within cells. PPAHV plays a significant role in elucidating the complex interplay of cellular signaling pathways, making it a relevant chemical for various experimental studies.
PPAHV (CAS 175796-50-6) References
- Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1. | Szallasi, A., et al. 1999. Br J Pharmacol. 128: 428-34. PMID: 10510454
- Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism. | Macho, A., et al. 2000. Chem Biol. 7: 483-92. PMID: 10903936
- Functional and desensitizing effects of the novel synthetic vanilloid-like agent 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) in the perfused rat hindlimb. | Griffiths, CD., et al. 2000. Br J Pharmacol. 131: 1408-12. PMID: 11090114
- Differences in sensitivity of vanilloid receptor 1 transfected to human embryonic kidney cells and capsaicin-activated channels in cultured rat dorsal root ganglion neurons to capsaicin receptor agonists. | Shin, JS., et al. 2001. Neurosci Lett. 299: 135-9. PMID: 11166956
- Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. | Ohnuki, K., et al. 2001. Biosci Biotechnol Biochem. 65: 2735-40. PMID: 11826971
- Cloning and functional characterization of the guinea pig vanilloid receptor 1. | Savidge, J., et al. 2002. Neuropharmacology. 43: 450-6. PMID: 12243775
- Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1. | Phillips, E., et al. 2004. J Biol Chem. 279: 17165-72. PMID: 14960593
- Cloning and pharmacological characterization of mouse TRPV1. | Correll, CC., et al. 2004. Neurosci Lett. 370: 55-60. PMID: 15489017
- Cloning and functional characterization of dog transient receptor potential vanilloid receptor-1 (TRPV1). | Phelps, PT., et al. 2005. Eur J Pharmacol. 513: 57-66. PMID: 15878709
- Molecular cloning, functional characterization of the porcine transient receptor potential V1 (pTRPV1) and pharmacological comparison with endogenous pTRPV1. | Ohta, T., et al. 2005. Biochem Pharmacol. 71: 173-87. PMID: 16288992
- An exploration of the estrogen receptor transcription activity of capsaicin analogues via an integrated approach based on in silico prediction and in vitro assays. | Li, J., et al. 2014. Toxicol Lett. 227: 179-88. PMID: 24747365
- Synthesis and evaluation of phorboid 20-homovanillates: discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity. | Appendino, G., et al. 1996. J Med Chem. 39: 3123-31. PMID: 8759633
- A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor. | Szallasi, A., et al. 1996. Eur J Pharmacol. 299: 221-8. PMID: 8901026
- A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons. | Liu, L., et al. 1998. Neuroscience. 84: 569-81. PMID: 9539227
Activator of:
VR1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PPAHV, 1 mg | sc-202296 | 1 mg | $135.00 |