Molecular structure of PPACK II, Trifluoroacetate Salt, CAS Number: 74392-49-7
PPACK II, Trifluoroacetate Salt (CAS 74392-49-7)
See product citations (2)
Application:
PPACK II, Trifluoroacetate Salt is a potent, specific and irreversible glandular and plasma kallikrein inhibitor
CAS Number:
74392-49-7
Purity:
Purity >95%
Molecular Weight:
729.1
Molecular Formula:
C27H34ClF3N6O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PPACK II, Trifluoroacetate Salt, also known as D-Phe-Pro-Arg-chloromethylketone, trifluoroacetate salt, is a highly potent and irreversible serine protease inhibitor. It specifically targets thrombin, a key enzyme in the coagulation cascade that converts fibrinogen to fibrin, leading to blood clot formation. By irreversibly binding to the active site of thrombin, PPACK II effectively inhibits its proteolytic activity. The chemical modification with trifluoroacetate enhances the compound′s solubility and stability, making it useful for various laboratory applications.
PPACK II, Trifluoroacetate Salt (CAS 74392-49-7) References
- Elevated kallikrein activity in plasma from stable liver transplant recipients. | Hayashi, J., et al. 2002. Int Immunopharmacol. 2: 1667-80. PMID: 12469941
- Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker. | Richards, RI., et al. 1991. Genomics. 11: 77-82. PMID: 1684954
- Immobilization of the irreversible thrombin inhibitor D-Phe-Pro-Arg-chloromethylketone: a concept for hemocompatible surfaces? | Maitz, MF., et al. 2010. J Biomed Mater Res A. 94: 905-12. PMID: 20730927
- Apolipoprotein B-100 of plasma low density lipoproteins undergoes proteolysis by contact activation factors when plasma is treated with dextran sulfate-500-MgCl2. | Byrne, RE. and Scanu, AM. 1989. J Lipid Res. 30: 109-20. PMID: 2465366
- Glandular kallikrein-like enzyme in adrenal glands. | Scicli, G., et al. 1989. Adv Exp Med Biol. 247B: 217-22. PMID: 2610063
- The conversion of atrial natriuretic peptide (ANP)-(1-126) to ANP-(99-126) by rat serum: contribution to ANP cleavage in isolated perfused rat hearts. | Gibson, TR., et al. 1987. Endocrinology. 120: 764-72. PMID: 2948815
- Inactivation of trypsin-like enzymes with peptides of arginine chloromethyl ketone. | Kettner, C. and Shaw, E. 1981. Methods Enzymol. 80 Pt C: 826-42. PMID: 6210829
- Enzymatic activities of activated and zymogen forms of human Hageman factor (factor XII). | Silverberg, M. and Kaplan, AP. 1982. Blood. 60: 64-70. PMID: 6979361
Inhibitor of:
Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PPACK II, Trifluoroacetate Salt, 10 mg | sc-203215 | 10 mg | $260.00 |