PP5 Antibody (F-12): sc-271817

PP5 Antibody (F-12) is a mouse monoclonal IgG3 antibody that detects PP5 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PP5, also known as Protein phosphatase T, plays a crucial role in cellular regulation by dephosphorylating serine residues on various substrates, including skeletal muscle phosphorylase and histone H1, which are vital for processes such as mitosis and RNA biogenesis. PP5 (F-12) antibody targets a protein predominantly located in the nucleus, where PP5 is involved in the regulation of gene expression and cell cycle progression, making PP5 essential for maintaining cellular homeostasis and proper cell division. The unique structure of PP5, which includes a catalytic domain and regulatory elements, allows PP5 to interact with specific proteins like CDC16 and CDC27, further emphasizing PP5′s importance in the intricate network of cellular signaling pathways. Anti-PP5 antibody (F-12) enables researchers to gain valuable insights into the functional dynamics of PP5 and its implications in various biological processes and diseases.

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PP5 Antibody (F-12) References:

1. Induction of abnormal nuclear shapes in two distinct modes by overexpression of serine/threonine protein phosphatase 5 in Hela cells.  |  Fukuda, H., et al. 2007. J Cell Biochem. 101: 321-30. PMID: 17171648
2. Insights into the key interactions between human protein phosphatase 5 and cantharidin using molecular dynamics and site-directed mutagenesis bioassays.  |  Liu, JY., et al. 2015. Sci Rep. 5: 12359. PMID: 26190207
3. miR-21-mediated Radioresistance Occurs via Promoting Repair of DNA Double Strand Breaks.  |  Hu, B., et al. 2017. J Biol Chem. 292: 3531-3540. PMID: 28096467
4. A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans.  |  Lyons, SP., et al. 2018. Mol Cell Proteomics. 17: 2448-2461. PMID: 30228194
5. Oxidized Products of α-Linolenic Acid Negatively Regulate Cellular Survival and Motility of Breast Cancer Cells.  |  Gutierrez-Pajares, JL., et al. 2019. Biomolecules. 10: PMID: 31905626
6. Re-evaluating the pathogenicity of the c.783+2T>C BAP1 germline variant.  |  Goldberg, Y., et al. 2021. Hum Mutat. 42: 592-599. PMID: 33600035
7. Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) inhibits cutaneous squamous cell carcinoma cell proliferation via targeting PP2A/PP5-mediated MAPK signaling pathway.  |  Liu, J., et al. 2021. Int J Biochem Cell Biol. 137: 106036. PMID: 34217813
8. Consistency of variant interpretations among bioinformaticians and clinical geneticists in hereditary cancer panels.  |  Agaoglu, NB., et al. 2022. Eur J Hum Genet. 30: 378-383. PMID: 35132179
9. Design and Synthesis of 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid Derivatives as PP5 Inhibitors To Reverse Temozolomide Resistance in Glioblastoma Multiforme.  |  Li, Z., et al. 2024. J Med Chem. 67: 15691-15710. PMID: 39136241
10. Placental protein 5 (PP5) in pregnancy and malignant disease: the influence of heparin binding.  |  Nisbet, AD., et al. 1982. Clin Chim Acta. 119: 21-9. PMID: 7060273

The preferred PP5 antibody is PP5 Antibody (H-7): sc-271816.