Date published: 2026-5-18

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POV-PC (CAS 121324-31-0)

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Application:
POV-PC is an oxLDL with effects on cell signaling and binding
CAS Number:
121324-31-0
Purity:
>98%
Molecular Weight:
593.7
Molecular Formula:
C29H56NO9P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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POV-PC, or 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine, is a phospholipid that may play a role in biological studies, particularly in the context of lipid oxidation products. POV-PC may incorporate into cellular membranes, where it can participate in the processes that lead to oxidative stress and inflammation. POV-PC may be used to model the effects of oxidized lipids within biological systems, aiding in the study of cellular responses to oxidative damage and the mechanisms underlying inflammation. By mimicking the properties of lipid peroxidation byproducts, POV-PC helps to understand the impact of such compounds on cell signaling, inflammation, and pathophysiological conditions associated with oxidative stress. Its role in these applications makes it useful for understanding how cells react to and manage oxidative challenges.


POV-PC (CAS 121324-31-0) References

  1. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils.  |  Leitinger, N., et al. 1999. Proc Natl Acad Sci U S A. 96: 12010-5. PMID: 10518567
  2. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species.  |  Podrez, EA., et al. 2000. J Clin Invest. 105: 1095-108. PMID: 10772654
  3. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36.  |  Podrez, EA., et al. 2002. J Biol Chem. 277: 38503-16. PMID: 12105195
  4. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions.  |  Podrez, EA., et al. 2002. J Biol Chem. 277: 38517-23. PMID: 12145296
  5. Oxidized phosphatidylcholines: pattern recognition ligands for multiple pathways of the innate immune response.  |  Hazen, SL. and Chisolm, GM. 2002. Proc Natl Acad Sci U S A. 99: 12515-7. PMID: 12271150
  6. Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion.  |  Barlic, J., et al. 2009. J Immunol. 182: 7928-36. PMID: 19494317
  7. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.  |  Seimon, TA., et al. 2010. Cell Metab. 12: 467-82. PMID: 21035758
  8. Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.  |  Ajiro, Y., et al. 2011. Am J Physiol Heart Circ Physiol. 301: H2395-401. PMID: 21949111
  9. Myeloid Krüppel-like factor 4 deficiency augments atherogenesis in ApoE-/- mice--brief report.  |  Sharma, N., et al. 2012. Arterioscler Thromb Vasc Biol. 32: 2836-8. PMID: 23065827
  10. Oxidized Low-Density Lipoprotein Induces Macrophage Production of Prothrombotic Microparticles.  |  Marchini, JF., et al. 2020. J Am Heart Assoc. 9: e015878. PMID: 32750308

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

POV-PC, 1 mg

sc-205441
1 mg
$108.00

POV-PC, 10 mg

sc-205441A
10 mg
$1163.00