Posaconazole-d4 (CAS 1133712-26-1)
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Posaconazole-d4 is often utilized in research applications as a stable isotope-labeled internal standard for mass spectrometry-based analytical methods. This compound′s primary function is to facilitate the accurate quantification of posaconazole levels in biological matrices, which is essential for chemical kinetic studies. In such applications, the deuterium atoms of Posaconazole-d4 provide a mass difference that allows for differentiation from the non-labeled substance, while its chemical behavior remains nearly identical to that of the unlabeled compound, ensuring that it serves as an appropriate control. The compound is also valuable in the investigation of environmental persistence and degradation pathways of posaconazole, as the labeled atoms can be traced through various processes. Moreover, Posaconazole-d4 is used in the study of metabolic stability and identifying metabolites through metabolic profiling techniques.
Posaconazole-d4 (CAS 1133712-26-1) References
- Liquid chromatography-mass spectrometry method for the quantification of posaconazole in human plasma: application to pharmacokinetics following single-dose administration in the fasted state and with a high-fat meal. | Xu, HR., et al. 2013. Pharmazie. 68: 173-7. PMID: 23556334
- A rapid UPLC-MS/MS assay for the simultaneous measurement of fluconazole, voriconazole, posaconazole, itraconazole, and hydroxyitraconazole concentrations in serum. | Basu, SS., et al. 2017. Clin Chem Lab Med. 55: 836-844. PMID: 27866173
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Posaconazole-d4, 500 µg | sc-219630 | 500 µg | $612.00 | |||
Posaconazole-d4, 1 mg | sc-219630A | 1 mg | $969.00 |