Pontin 52 Antibody (2943C1a): sc-81360
- Pontin 52 Antibody (2943C1a) is a mouse monoclonal IgG2b, cited in 1 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of Pontin 52 of human origin
- recommended for detection of Pontin 52 of mouse, rat and human origin by WB, IP and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pontin 52 Antibody (2943C1a). This work is in progress.
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Pontin 52 Antibody (2943C1a) is a mouse monoclonal IgG2b antibody that detects Pontin 52 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Pontin 52, also known as RUVBL1 or NMP 238, is a crucial nuclear matrix protein primarily localized in the nucleoplasm of cells, where Pontin 52 plays a significant role in various cellular processes. Anti-Pontin 52 antibody (2943C1a) recognizes a protein involved in the regulation of transcription and essential for the oncogenic activity of the Myc protein, as Pontin 52 forms a complex with Myc and Reptin 52 (RUVBL2), another related protein. This interaction is vital for Myc′s function in promoting cell proliferation and transformation, highlighting Pontin 52′s importance in cancer biology. The gene encoding human Pontin 52 is located on chromosome 3q21, and Pontin 52′s ATPase/helicase motif suggests a role in unwinding DNA or RNA, further emphasizing Pontin 52′s significance in gene expression regulation. Pontin 52 monoclonal antibody (2943C1a) serves as a valuable tool for researchers studying cancer mechanisms and cellular signaling pathways through Pontin 52′s interactions with key proteins involved in oncogenesis.
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Pontin 52 Antibody (2943C1a) References:
- Chromosome Missegregation Associated with RUVBL1 Deficiency. | Gentili, C., et al. 2015. PLoS One. 10: e0133576. PMID: 26201077
- RUVBL1-ITFG1 interaction is required for collective invasion in breast cancer. | Fan, W., et al. 2017. Biochim Biophys Acta Gen Subj. 1861: 1788-1800. PMID: 28341484
- Deregulated levels of RUVBL1 induce transcription-dependent replication stress. | Hristova, RH., et al. 2020. Int J Biochem Cell Biol. 128: 105839. PMID: 32846207
- RUVBL1 promotes enzalutamide resistance of prostate tumors through the PLXNA1-CRAF-MAPK pathway. | Sun, F., et al. 2022. Oncogene. 41: 3239-3250. PMID: 35508542
- Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling. | Chen, T., et al. 2022. Theranostics. 12: 7450-7464. PMID: 36438486
- Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis. | Li, M., et al. 2023. Adv Sci (Weinh). 10: e2206584. PMID: 37075745
- RUVBL1 accelerates tongue squamous cell carcinoma by mediating CRaf/MEK/ERK pathway. | Zhang, XY., et al. 2024. iScience. 27: 109434. PMID: 38523780
- RUVBL1 ubiquitination by DTL promotes RUVBL1/2-β-catenin-mediated transcriptional regulation of NHEJ pathway and enhances radiation resistance in breast cancer. | Tian, J., et al. 2024. Cell Death Dis. 15: 259. PMID: 38609375
- RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis. | Chen, D., et al. 2024. Cancer Res. 84: 2856-2872. PMID: 38900944
- The Lyn/RUVBL1 Complex Promotes Colorectal Cancer Liver Metastasis by Regulating Arachidonic Acid Metabolism Through Chromatin Remodeling. | Zhang, Z., et al. 2025. Adv Sci (Weinh). 12: e2406562. PMID: 39665272
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pontin 52 Antibody (2943C1a) | sc-81360 | 100 µg/ml | $339.00 |