POM 1 (CAS 12141-67-2)
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POM 1 is a chemical compound known as a potent and selective inhibitor of the enzyme ecto-apyrase (CD39), which is involved in the hydrolysis of ATP to ADP and AMP. In research, POM 1 is used to study the purinergic signaling pathway, which plays a role in various physiological processes. By inhibiting CD39 activity, POM 1 allows scientists to investigate the consequences of altered extracellular nucleotide levels and their impact on cellular function and communication. The use of POM 1 in research has contributed to a better understanding of the pathophysiological roles of CD39 in disease models and has provided insights into the regulation of the extracellular nucleotide environment. Research involving POM 1 is often directed toward elucidating the mechanisms by which purinergic signaling influences the progression of diseases and the identification of potential targets for new research tools.
POM 1 (CAS 12141-67-2) References
- Purification of Hydrogenase from Chlamydomonas reinhardtii. | Roessler, PG. and Lien, S. 1984. Plant Physiol. 75: 705-9. PMID: 16663691
- Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. | Müller, CE., et al. 2006. Bioorg Med Chem Lett. 16: 5943-7. PMID: 16997558
- Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. | Grenz, A., et al. 2007. FASEB J. 21: 2863-73. PMID: 17442731
- Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. | Corriden, R., et al. 2008. J Biol Chem. 283: 28480-6. PMID: 18713747
- The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. | Wall, MJ., et al. 2008. Neuropharmacology. 55: 1251-8. PMID: 18768144
- Generation and detection of gaseous W12O41-* and other tungstate anions by laser desorption ionization mass spectrometry. | Pavlov, J., et al. 2009. J Am Soc Mass Spectrom. 20: 1782-9. PMID: 19631558
- Tungsten speciation and toxicity: acute toxicity of mono- and poly-tungstates to fish. | Strigul, N., et al. 2010. Ecotoxicol Environ Saf. 73: 164-71. PMID: 19836837
- Ectonucleotidases in the digestive system: focus on NTPDase3 localization. | Lavoie, EG., et al. 2011. Am J Physiol Gastrointest Liver Physiol. 300: G608-20. PMID: 21233276
- Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. | Pinheiro, AR., et al. 2013. Cell Commun Signal. 11: 70. PMID: 24047499
- Regulatory T cell-derived adenosine induces dendritic cell migration through the Epac-Rap1 pathway. | Ring, S., et al. 2015. J Immunol. 194: 3735-44. PMID: 25780038
- CD39 is a promising therapeutic antibody target for the treatment of soft tissue sarcoma. | Hayes, GM., et al. 2015. Am J Transl Res. 7: 1181-8. PMID: 26279761
- Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling. | Wan, P., et al. 2016. Sci Rep. 6: 19108. PMID: 26739809
- Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe. | Hawkins, VE., et al. 2017. Elife. 6: PMID: 28387198
- CD39 identifies a microenvironment-specific anti-inflammatory CD8+ T-cell population in atherosclerotic lesions. | van Duijn, J., et al. 2019. Atherosclerosis. 285: 71-78. PMID: 31048101
- Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism. | Spatola, BN., et al. 2020. MAbs. 12: 1838036. PMID: 33146056
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
POM 1, 50 g | sc-203205 | 50 g | $163.00 | |||
POM 1, 250 g | sc-203205A | 250 g | $433.00 |