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POM 1(Sodium polyoxotungstate) belongs to a group of polyoxotungstates that inhibits CD39, CD39L1, CD39L3 (nucleoside-triphosphate-diphosphohydrolases). POM 1 is a non-specific inhibitor of NTPDase8 (ecto-nucleoside-triphosphate-diphosphohydrolases) and has been observed to inhibit renal protection activated through ischemic preconditioning (IP). This compound displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 (Ki values are 2.58 vs 28.8 μM, respectively). Studies have shown that POM 1 is more potent at blocking ATP breakdown than ARL 67156 (sc-203521) in cerebellar slices and can also block central synaptic transmission, which is independent of the NTPDase inhibition. POM 1 is the anhydrous form of sc-253591. POM 1 is an inhibitor of P2Y12.
1. Müller, C.E., et al. 2006. Bioorg. Med. Chem. Lett. 16: 5943-5947. PMID: 16997558
2. Grenz, A., et al. 2007. FASEB J. 21: 2863-2873. PMID: 17442731
3. Wall, M.J., et al. 2008. Neuropharmacology. 55: 1251-1258. PMID: 18768144
See how others have used POM 1. Click on the entry to view the PubMed entry .
PMID: # 27347331 Li, K. et al. 2016. Am J Transl Res. 8: 2245-54.
PMID: # 26773142 Ujiie, H. et al. 2016. Journal of immunology (Baltimore, Md. : 1950). 196: 1517-28.
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