POM 1 CAS: 12141-67-2
MF: Na6O39W12•H2O
MW: 2986.13
An inhibitor of NTPDases and the breakdown of ATP activated by IP.

POM 1 (CAS 12141-67-2)

POM 1 | CAS 12141-67-2 is rated 5.0 out of 5 by 1.
  • y_2020, m_2, d_24, h_12
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203205, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 153ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: Sodium metatungstate; Sodium polytungstate
Application: An inhibitor of NTPDases and the breakdown of ATP activated by IP
CAS Number: 12141-67-2
Molecular Weight: 2986.13
Molecular Formula: Na6O39W12•H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

POM 1(Sodium polyoxotungstate) belongs to a group of polyoxotungstates that inhibits CD39, CD39L1, CD39L3 (nucleoside-triphosphate-diphosphohydrolases). POM 1 is a non-specific inhibitor of NTPDase8 (ecto-nucleoside-triphosphate-diphosphohydrolases) and has been observed to inhibit renal protection activated through ischemic preconditioning (IP). This compound displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 (Ki values are 2.58 vs 28.8 μM, respectively). Studies have shown that POM 1 is more potent at blocking ATP breakdown than ARL 67156 (sc-203521) in cerebellar slices and can also block central synaptic transmission, which is independent of the NTPDase inhibition. POM 1 is the anhydrous form of sc-253591. POM 1 is an inhibitor of P2Y12.


References

1. Müller, C.E., et al. 2006. Bioorg. Med. Chem. Lett. 16: 5943-5947. PMID: 16997558
2. Grenz, A., et al. 2007. FASEB J. 21: 2863-2873. PMID: 17442731
3. Wall, M.J., et al. 2008. Neuropharmacology. 55: 1251-1258. PMID: 18768144

Physical State :
Solid
Solubility :
Soluble in water (4000 mg/ml), and fat (< 7 mg/ml at 37° C).
Storage :
Store at room temperature
Density :
5.47 g/cm3
Ki Data :
NTPDase 1: Ki= 2.58 µM; NTPDase 3: Ki= 3.26 µM; P2Y12 : Ki= >10 µM; NTPDase 2 : Ki= 28.8 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
PubChem CID :
3084108
MDL Number :
MFCD00061466
EC Number :
412-770-9
SMILES :
[O-][W](=O)(=O)[O-].[O-][W](=O)(=O)[O-].[O-][W](=O)(=O)[O-].O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

POM 1  Product Citations

See how others have used POM 1. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27347331  Li, K. et al. 2016. Am J Transl Res. 8: 2245-54.

PMID: # 26773142  Ujiie, H. et al. 2016. Journal of immunology (Baltimore, Md. : 1950). 196: 1517-28.

Citations 1 to 2 of 2 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 122ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Wall Wall, MJ. et al. (PubMed 18768144) reported that the novel NTPDase inhibitor Sodium polyoxotungstate (POM-1) inhibits ATP breakdown and also blocks central synaptic transmission, an action independent of NTPDase inhibition. -SCBT Publication Review
Date published: 2015-04-30
  • y_2020, m_2, d_24, h_12
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203205, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 21ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.