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Polysorbate 80 (CAS 9005-65-6)

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Alternate Names:
Tween 80
Application:
Polysorbate 80 is a non ionic detergent for cell lysis
CAS Number:
9005-65-6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Polysorbate 80 is a non ionic detergent used for cell lysis, nuclei isolationand cell fractionation Bulk pricing available Polysorbate 80, a polyethylene sorbitol ester, is widely employed as a stabilizer and emulsifier in various commercial applications. With its surfactant properties, Polysorbate 80 acts as an effective agent for enhancing the stability and uniform dispersion of ingredients in formulations. It belongs to the group of polysorbates, which consist of sorbitol and sorbitane oleic esters combined with polyethylene glycol chains, further contributing to their emulsifying capabilities and versatile applications.


Polysorbate 80 (CAS 9005-65-6) References

  1. Polysorbates 20 and 80 used in the formulation of protein biotherapeutics: structure and degradation pathways.  |  Kerwin, BA. 2008. J Pharm Sci. 97: 2924-35. PMID: 17973307
  2. Safety of Polysorbate 80 in the Oncology Setting.  |  Schwartzberg, LS. and Navari, RM. 2018. Adv Ther. 35: 754-767. PMID: 29796927
  3. Brain-Targeted Polysorbate 80-Emulsified Donepezil Drug-Loaded Nanoparticles for Neuroprotection.  |  Tao, X., et al. 2021. Nanoscale Res Lett. 16: 132. PMID: 34406517
  4. Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites.  |  Zhou, X., et al. 2022. J Colloid Interface Sci. 606: 1928-1939. PMID: 34695760
  5. Polysorbate 80-Induced Anaphylactoid Reaction and the Effects on Cardiovascular Function: Dose Threshold and Species Comparison.  |  Pouliot, M., et al. 2022. Int J Toxicol. 41: 99-107. PMID: 35245984
  6. Threshold for Anaphylactoid Reaction to Polysorbate 80 in Canines.  |  Holbrook, K., et al. 2022. Int J Toxicol. 41: 89-98. PMID: 35337210
  7. Polysorbate 80 and histidine quantitative analysis by NMR in the presence of virus-like particles.  |  Rustandi, RR. 2022. Electrophoresis. 43: 1408-1414. PMID: 35366009
  8. Lack of an Effect of Polysorbate 80 on Intestinal Drug Permeability in Humans.  |  Metry, M., et al. 2022. Pharm Res. 39: 1881-1890. PMID: 35672541
  9. Characterization of radicals in polysorbate 80 using electron paramagnetic resonance (EPR) spectroscopy and spin trapping.  |  Mittag, JJ., et al. 2022. Int J Pharm X. 4: 100123. PMID: 35795322
  10. Polysorbate 80 improves the adhesion and survival of yogurt starters with cholesterol uptake abilities.  |  Ziar, H. and Riazi, A. 2022. Saudi J Biol Sci. 29: 103367. PMID: 35846386
  11. Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions.  |  Li, Y., et al. 2022. BMC Pharmacol Toxicol. 23: 52. PMID: 35850712
  12. Antimicrobial Activity of Polysorbate 80-iodine Complex: Polysorbate 80 Firmly Retains Iodine.  |  Yano, S., et al. 2022. J Oleo Sci. 71: 1639-1645. PMID: 36198581
  13. Polysorbate 80 blocked a peripheral sodium channel, Nav1.7, and reduced neuronal excitability.  |  Kim, RE. and Choi, JS. 2023. Mol Pain. 19: 17448069221150138. PMID: 36550597
  14. Polysorbate 80 hypersensitivity.  |  Shelley, WB., et al. 1995. Lancet. 345: 1312-3. PMID: 7746084

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Polysorbate 80, 100 ml

sc-255444
100 ml
$23.00

Polysorbate 80, 500 ml

sc-255444A
500 ml
$41.00

Polysorbate 80, 1 L

sc-255444B
1 L
$51.00

Polysorbate 80, 5 L

sc-255444C
5 L
$153.00

Is the Polysorbate 80 food grade (FCC)?

Asked by: Entoura
Thank you for your question. All of our products are of research grade quality and are not suitable for any applications calling for a food or pharma grade product.
Answered by: Technical Support Europe
Date published: 2020-10-08

What is the color of sc-255444, is it yellow or transparent?

Asked by: two2igm05
Thank you for your question. Polysorbate 80, sc-255444, is yellow in color.
Answered by: Chemical Support 4
Date published: 2017-04-06
  • y_2025, m_9, d_24, h_6CST
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Rated 5 out of 5 by from Various publications cite the use of PolysorbateVarious publications cite the use of Polysorbate 80 for cell lysis, nuclei isolation, and cell fractionation. -SCBT Publication Review
Date published: 2015-01-17
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Polysorbate 80 is rated 5.0 out of 5 by 1.
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