Date published: 2026-5-10

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Polyoxyethylenesorbitan monopalmitate (CAS 9005-66-7)

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Alternate Names:
Tween 40
Application:
Polyoxyethylenesorbitan monopalmitate is a non-ionic detergent used for cell lysis and cell fractionation
CAS Number:
9005-66-7
Molecular Weight:
~1277
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Polyoxyethylenesorbitan monopalmitate, also known as polysorbate 40, is a commonly used chemical in scientific research due to its versatile properties and wide range of applications. Researchers have explored its mechanisms of action and harnessed its potential in various research areas. One significant application of Polyoxyethylenesorbitan monopalmitate is in the field of emulsions and colloidal systems. It acts as an emulsifier and stabilizer, facilitating the formation and stabilization of oil-in-water emulsions. Polysorbate 40 achieves this by reducing the interfacial tension between oil and water phases, allowing for the formation of fine and stable emulsions. This property has been utilized in various research fields, including food science, cosmetics, and material science, where the formation and stability of emulsions are crucial. Additionally, Polyoxyethylenesorbitan monopalmitate has been employed in drug delivery research. It has the ability to enhance the solubility and bioavailability of poorly soluble drugs by forming micelles or emulsions that can encapsulate the drug molecules. This mechanism improves the drug′s dispersibility and absorption, enabling its effective delivery. Furthermore, Polysorbate 40 has found applications in cell culture research, where it acts as a dispersing agent for hydrophobic compounds such as vitamins and hormones in cell culture media. By unraveling the complex mechanisms and applications of Polyoxyethylenesorbitan monopalmitate, researchers continue to expand our understanding of emulsion science, drug delivery systems, and cell culture techniques, offering innovative solutions in various scientific research fields.


Polyoxyethylenesorbitan monopalmitate (CAS 9005-66-7) References

  1. Use of Tween 40 and Tween 80 to deliver a mixture of phytochemicals to human colonic adenocarcinoma cell (CaCo-2) monolayers.  |  O'Sullivan, SM., et al. 2004. Br J Nutr. 91: 757-64. PMID: 15137928
  2. Tween 40-based precipitate production observed on modified chromogenic agar and development of biological identification kit for Malassezia species.  |  Kaneko, T., et al. 2006. Med Mycol. 44: 227-31. PMID: 16702101
  3. Tween 40 pretreatment of unwashed water-insoluble solids of reed straw and corn stover pretreated with liquid hot water to obtain high concentrations of bioethanol.  |  Lu, J., et al. 2013. Biotechnol Biofuels. 6: 159. PMID: 24206614
  4. Effect of Tween 40 and DtsR1 on L-arginine overproduction in Corynebacterium crenatum.  |  Chen, M., et al. 2015. Microb Cell Fact. 14: 119. PMID: 26264811
  5. pKa values of hyodeoxycholic and cholic acids in the binary mixed micelles sodium-hyodeoxycholate-Tween 40 and sodium-cholate-Tween 40: Thermodynamic stability of the micelle and the cooperative hydrogen bond formation with the steroid skeleton.  |  Poša, M., et al. 2017. Steroids. 117: 62-70. PMID: 27651024
  6. Tween-20 transiently changes the surface morphology of PK-15 cells and improves PCV2 infection.  |  Hua, T., et al. 2018. BMC Vet Res. 14: 138. PMID: 29699558
  7. Proteome analysis guided genetic engineering of Corynebacterium glutamicum S9114 for tween 40-triggered improvement in L-ornithine production.  |  Jiang, Y., et al. 2020. Microb Cell Fact. 19: 2. PMID: 31906967
  8. Effect of tween 40 and ethanol on the secretion, structure and antioxidant activities of exopolysaccharides from Inonotus rickii.  |  Bai, J., et al. 2020. An Acad Bras Cienc. 92 Suppl 2: e20180838. PMID: 32725044
  9. Interaction of HPC with CTAB and Tween 40 at Water/Air and Water/Soya Oil Interfaces.  |  Masrat, R. and Dar, AA. 2023. Langmuir.. PMID: 36622144

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Polyoxyethylenesorbitan monopalmitate, 100 ml

sc-255442
100 ml
$37.00

Polyoxyethylenesorbitan monopalmitate, 500 ml

sc-255442A
500 ml
$55.00