Polyoma virus VP1 Antibody (3D10): sc-65925

Polyoma virus VP1 Antibody (3D10) is a mouse monoclonal IgG1 antibody that detects the major capsid protein VP1 of hamster Polyomavirus by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Polyoma virus VP1 antibody (3D10) is available in a non-conjugated form, providing researchers with a versatile tool for studying the role of VP1 protein in viral pathogenesis. VP1 protein constitutes approximately 75% of the total capsid shell protein, forming a protective layer around the viral genome. This structural significance is vital for stability and infectivity, as capsid integrity is essential for virus entry into host cells and infection initiation. VP1 interaction with cellular proteins such as retinoblastoma protein and p53 contributes to tumor-inducing properties of JC virus, particularly in immunocompromised individuals, where infection can lead to severe neurological conditions like progressive multifocal leukoencephalopathy (PML). Understanding VP1 function and structure is important for developing therapeutic strategies against diseases associated with Polyoma viruses.

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Polyoma virus VP1 Antibody (3D10) References:

1. Modeling a sialic acid binding pocket in the external loops of JC virus VP1.  |  Gee, GV., et al. 2004. J Biol Chem. 279: 49172-6. PMID: 15347668
2. Generation of monoclonal antibodies of desired specificity using chimeric polyomavirus-derived virus-like particles.  |  Zvirbliene, A., et al. 2006. J Immunol Methods. 311: 57-70. PMID: 16516908
3. Serological diagnosis of human polyomavirus infection.  |  Lundstig, A. and Dillner, J. 2006. Adv Exp Med Biol. 577: 96-101. PMID: 16626030
4. Virus-like particles derived from major capsid protein VP1 of different polyomaviruses differ in their ability to induce maturation in human dendritic cells.  |  Gedvilaite, A., et al. 2006. Virology. 354: 252-60. PMID: 16904154
5. Hamster polyomavirus-derived virus-like particles are able to transfer in vitro encapsidated plasmid DNA to mammalian cells.  |  Voronkova, T., et al. 2007. Virus Genes. 34: 303-14. PMID: 16927120
6. Identification of a novel polyomavirus from patients with acute respiratory tract infections.  |  Gaynor, AM., et al. 2007. PLoS Pathog. 3: e64. PMID: 17480120
7. High prevalence of human polyomavirus JC VP1 gene sequences in pediatric malignancies.  |  Shiramizu, B., et al. 2007. Cell Mol Biol (Noisy-le-grand). 53: 4-12. PMID: 17531143
8. Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression.  |  Manley, K., et al. 2007. Virology. 366: 394-404. PMID: 17555786

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Polyoma virus VP1 Antibody (3D10) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Polyoma virus VP1 Antibody (3D10) Specifications

Alternate Product Name: Polyoma virus VP1

Product Clone Name: 3D10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Polyoma virus VP1

Epitope Species: hamster polyomavirus

Product Reactivity/Detection: major capsid protein VP1

Species Reactivity/Detection: hamster Polyomavirus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Polyoma virus VP1 Antibody (3D10): N/A