Molecular structure of Polyketomycin, CAS Number: 200625-47-4
Polyketomycin (CAS 200625-47-4)
See product citations (3)
Application:
Polyketomycin is a tetracyclic quinone glycoside with antibacterial activity
CAS Number:
200625-47-4
Molecular Weight:
864.9
Molecular Formula:
C44H48O18
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Polyketomycin is a tetracyclic quinone glycoside with antibacterial, antitumor, and antimalarial ativity produced by Streptomyces diastatochromogenes. Known as an anthracycline antibiotic displaying cytotoxic and growth inhibitory ability against Gram-positive multi drug strains including methicillin-resistant Staphylococcus aureus (MRSA). Shown in experiments to have potent antitumor activity against multiple cancer cell lines.
Polyketomycin (CAS 200625-47-4) References
- Biosynthesis of polyketomycin produced by Streptomyces diastatochromogenes Tü 6028. | Paululat, T., et al. 1999. J Antibiot (Tokyo). 52: 96-101. PMID: 10344562
- Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. | Daum, M., et al. 2009. Chembiochem. 10: 1073-83. PMID: 19266534
- Genome sequencing and annotation of Amycolatopsis azurea DSM 43854(T). | Khatri, I., et al. 2014. Genom Data. 2: 44-5. PMID: 26484067
- From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028. | Greule, A., et al. 2017. J Vis Exp.. PMID: 28117820
- Wide Distribution of Foxicin Biosynthetic Gene Clusters in Streptomyces Strains - An Unusual Secondary Metabolite with Various Properties. | Greule, A., et al. 2017. Front Microbiol. 8: 221. PMID: 28270798
- PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates. | Guo, X., et al. 2018. Biochemistry. 57: 1003-1011. PMID: 29341603
- Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs. | Kemung, HM., et al. 2018. Front Microbiol. 9: 2221. PMID: 30319563
- Biosynthesis of aromatic polyketides in microorganisms using type II polyketide synthases. | Wang, J., et al. 2020. Microb Cell Fact. 19: 110. PMID: 32448179
- Editorial: Actinobacteria: Prolific Producers of Bioactive Metabolites. | Lee, LH., et al. 2020. Front Microbiol. 11: 1612. PMID: 32973689
- Structural Insight of KSIII (β-Ketoacyl-ACP Synthase)-like Acyltransferase ChlB3 in the Biosynthesis of Chlorothricin. | Saeed, AU., et al. 2022. Molecules. 27: PMID: 36234941
- Antagonism of Rhizosphere Streptomyces yangpuensis CM253 against the Pathogenic Fungi Causing Corm Rot in Saffron (Crocus sativus L.). | Tian, L., et al. 2022. Pathogens. 11: PMID: 36297252
- Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. | Momose, I., et al. 1998. J Antibiot (Tokyo). 51: 21-5. PMID: 9531983
- Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. II. Structure determination. | Momose, I., et al. 1998. J Antibiot (Tokyo). 51: 26-32. PMID: 9531984
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Polyketomycin, 1 mg | sc-202294 | 1 mg | $294.00 |