Polygodial pyridazine (CAS 1810726-08-9)

Polygodial pyridazine, a synthetic derivative of polygodial—a natural sesquiterpene dialdehyde—is recognized for its distinctive structural and chemical properties. The introduction of a pyridazine ring into the polygodial structure enhances its biochemical activity, making it a notable subject in chemical and biological research. The primary action of polygodial pyridazine centers on its interaction with cell membranes, particularly influencing membrane integrity and permeability. It disrupts cellular membranes through mechanisms likely involving either direct interaction with lipids or binding to membrane-associated proteins. This disruption can lead to rapid changes in cellular ion gradients and induce cell death, making it a potent cytotoxic agent. Polygodial pyridazine has been employed to explore various biological phenomena, such as the mechanisms underlying cell membrane integrity, cell signaling pathways related to stress and cytotoxicity, and the cellular responses to external chemical insults. The compound′s ability to alter membrane properties provides a useful tool for dissecting the role of membrane dynamics in cellular health and pathology.