Date published: 2026-4-24

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Polyglycerine (CAS 25618-55-7)

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CAS Number:
25618-55-7
Molecular Formula:
(C3H8O3)n
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Polyglycerine, also known as Glycerol or glycerine, is a syrupy liquid that is clear, odorless, and possesses a sweet taste. As a simple polyol compound, it holds great significance as a constituent of lipids, found universally across living organisms. Its colorless and odorless nature, coupled with its viscous consistency, renders it highly versatile in various industries, particularly pharmaceutical formulations and food products. With its multifaceted utility as a humectant, lubricant, solvent, and preservative, Polyglycerine garners widespread employment in diverse sectors. It serves as a solvent and cryoprotectant in cell culture, and freezing of tissue samples. Moreover, Polyglycerine finds application in the preparation of cell suspensions and as a cryoprotectant during cell and tissue freezing. Furthermore, it acts as a cryoprotectant in preserving proteins, enzymes, and other biomolecules.


Polyglycerine (CAS 25618-55-7) References

  1. Dendritic polyglycerol: a new versatile biocompatible-material.  |  Frey, H. and Haag, R. 2002. J Biotechnol. 90: 257-67. PMID: 12071228
  2. Phase behavior of polyglycerol didodecanoates in water.  |  Kunieda, H., et al. 2002. J Colloid Interface Sci. 245: 365-70. PMID: 16802456
  3. Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA.  |  Kainthan, RK., et al. 2006. Biomaterials. 27: 5377-90. PMID: 16854460
  4. Hyperbranched polyglycerols: from the controlled synthesis of biocompatible polyether polyols to multipurpose applications.  |  Wilms, D., et al. 2010. Acc Chem Res. 43: 129-41. PMID: 19785402
  5. Linear poly(methyl glycerol) and linear polyglycerol as potent protein and cell resistant alternatives to poly(ethylene glycol).  |  Weinhart, M., et al. 2010. Chem Asian J. 5: 1992-2000. PMID: 20602410
  6. Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration.  |  Abu Lila, AS., et al. 2013. Int J Pharm. 456: 235-42. PMID: 23928149
  7. Application of polyglycerol coating to plasmid DNA lipoplex for the evasion of the accelerated blood clearance phenomenon in nucleic acid delivery.  |  Abu Lila, AS., et al. 2014. J Pharm Sci. 103: 557-66. PMID: 24347396
  8. Reversible hemostatic properties of sulfabetaine/quaternary ammonium modified hyperbranched polyglycerol.  |  Wen, J., et al. 2016. Biomaterials. 86: 42-55. PMID: 26885776
  9. Enzymatic Synthesis of Polyglycerol Fatty Acid Esters and Their Application as Emulsion Stabilizers.  |  Peng, B., et al. 2018. J Agric Food Chem. 66: 8104-8113. PMID: 29989410
  10. Red fluorescent ZnO nanoparticle grafted with polyglycerol and conjugated RGD peptide as drug delivery vehicles for efficient target cancer therapy.  |  Yang, X., et al. 2019. Mater Sci Eng C Mater Biol Appl. 95: 104-113. PMID: 30573230
  11. Synthesis and Characterization of Dendritic and Linear Glycol Methacrylates and Their Performance as Marine Antifouling Coatings.  |  Wanka, R., et al. 2021. ACS Appl Mater Interfaces. 13: 6659-6669. PMID: 33497184
  12. Polyglycerol for Half-Life Extension of Proteins-Alternative to PEGylation?  |  Tully, M., et al. 2021. Biomacromolecules. 22: 1406-1416. PMID: 33792290
  13. Steric Interaction of Polyglycerol-Functionalized Detonation Nanodiamonds.  |  Yoshikawa, T., et al. 2022. Langmuir. 38: 661-669. PMID: 34985902

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Polyglycerine, 100 g

sc-495781
100 g
$624.00