Date published: 2025-12-18

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Polyethyleneimine, linear, M.W. 25,000 (CAS 9002-98-6)

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CAS Number:
9002-98-6
Molecular Weight:
~25,000
Molecular Formula:
-HN-[CH2CH2NH-]n
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Polyethyleneimine (PEI), particularly the linear form with a molecular weight (M.W.) of 25,000, is a synthetic polymer known for its high density of amine groups along the polymer backbone. This feature imparts the polymer with a strong cationic nature, making it highly effective in binding negatively charged particles, molecules, and cellular components. It is employed to enhance the characteristics of negatively charged dyes, augmenting their appearance and promoting their adhesion to surfaces. The polymer′s cationic nature allows it to form complexes with negatively charged nucleic acids, such as DNA and RNA, facilitating the encapsulation and protection of these molecules from enzymatic degradation. Furthermore, the PEI-nucleic acid complexes can interact with cell membranes, promoting cellular uptake through endocytosis.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences


Polyethyleneimine, linear, M.W. 25,000 (CAS 9002-98-6) References

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  3. Magnetic separation and antibiotics selection enable enrichment of cells with ZFN/TALEN-induced mutations.  |  Kim, H., et al. 2013. PLoS One. 8: e56476. PMID: 23441197
  4. Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA.  |  Ramakrishna, S., et al. 2014. Genome Res. 24: 1020-7. PMID: 24696462
  5. Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction by AAV2, But Not AAV8, Vectors in Murine Hepatocytes In Vivo.  |  Li, B., et al. 2015. Hum Gene Ther Methods. 26: 211-20. PMID: 26421998
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  8. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.  |  Breslow, DK., et al. 2018. Nat Genet. 50: 460-471. PMID: 29459677
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  12. The Vasopressin Receptor 2 Mutant R137L Linked to the Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) Signals through an Alternative Pathway that Increases AQP2 Membrane Targeting Independently of S256 Phosphorylation.  |  Ranieri, M., et al. 2020. Cells. 9: PMID: 32486031
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Polyethyleneimine, linear, M.W. 25,000, 250 mg

sc-507213
250 mg
$959.00