Polydatin CAS: 65914-17-2
MF: C20H22O8
MW: 390.38
A Resveratrol glycoside and inhibitor of platelet aggregation.

Polydatin (CAS 65914-17-2)

Polydatin | CAS 65914-17-2 is rated 5.0 out of 5 by 1.
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Alternate Names: Resveratrol 3-beta-mono-D-glucoside
Application: Polydatin is a Resveratrol glycoside and inhibitor of platelet aggregation
CAS Number: 65914-17-2
Purity: ≥98%
Molecular Weight: 390.38
Molecular Formula: C20H22O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Polydatin is the glycoside of Resveratrol (sc-200808) originally isolated from the Chinese herb Polygonum cuspidatum. The compound has been shown to inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. Myocardial cell, white blood cell, vascular smooth muscle cell, and endothelial cell studies report that Polydatin can inhibit ICAM-1 expression, elevate Ca2+, weaken white blood cell-endothelial cell adhesion, and activate KATP channels.


References

1. Soleas, G.J., et al. 1997. J. Clin. Lab. Anal. 11: 287-313. PMID: 9292395
2. Huang, Z.S., et al. 1999. World J. Gastroenterol. 5: 41-44. PMID: 11819383
3. Zhao, K.S., et al. 2003. Clin. Hemorheol. Microcirc. 29: 211-217. PMID: 14724344
4. Cheng, Y., et al. 2006. Brain Res. 1110: 193-200. PMID: 16870162
5. Du, J., et al. 2009. Phytomedicine. 16: 652-658. PMID: 19106037

Physical State :
Solid
Derived From :
Isolated from Polygonum cuspidatum.
Solubility :
Soluble in water (<1 mg/ml at 25° C), DMSO (78 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), methanol, and ethyl acetate.
Storage :
Store at 4° C
Melting Point :
223-226° C (lit.)
Boiling Point :
707.70° C at 760 mmHg (Predicted)
Density :
1.52 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
Optical Activity :
α20/D -55°, c = 1 in acetone; α20/D -66°±2°, c = 1 in ethanol; α20/D 72.9°, c = 0.34 in ethanol
IC50 :
ATPase activity of Tag : IC50 = 7.7 µM; RAW264.7: IC50 = 13.5 µM (mouse); Cupric ion-induced lipid peroxidation: IC50 = 19.1 µM (human LDL); Aldose reductase: IC50 = 100 µM (rat); DPPH radical scavenging activity: IC50 = 198 µM
pK Values :
pKa: 9.21 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
Merck Index :
14: 8158
MDL Number :
MFCD00210592
Beilstein Registry :
54837
SMILES :
C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O[[email protected]]3[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](O3)CO)O)O)O)O)O

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Certificate of Analysis

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Polydatin (CAS 65914-17-2)  Product Citations

See how others have used Polydatin (CAS 65914-17-2). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26616494  Wang, C.|Luo, Y.|Lu, J.|Wang, Y.|Sheng, G.| et al. 2016. J Biochem Mol Toxicol. 30: 200-5.

PMID: # 26253722  Kataria, H. et al. 2015. Mol. Neurobiol.

PMID: # 30191382  J Nat Med. 85-92.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Zeng Zeng, Z. et al. (PubMed 26301045) reported that Polydatin alleviates small intestine injury during hemorrhagic shock as a SIRT1 activator. -SCBT Publication Review
Date published: 2015-01-06
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