Date published: 2025-10-3

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Polydatin (CAS 65914-17-2)

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Alternate Names:
Resveratrol 3-beta-mono-D-glucoside
Application:
Polydatin is a Resveratrol glycoside and inhibitor of platelet aggregation
CAS Number:
65914-17-2
Purity:
≥98%
Molecular Weight:
390.38
Molecular Formula:
C20H22O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Polydatin is the glycoside of Resveratrol (sc-200808) originally isolated from the Chinese herb Polygonum cuspidatum. The compound may act to inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. Myocardial cell, white blood cell, vascular smooth muscle cell, and endothelial cell studies report that Polydatin can inhibit ICAM-1 expression, elevate Ca2+, weaken white blood cell-endothelial cell adhesion, and activate KATP channels. Polydatin is an inhibitor of Phospholipase A2. Notably, polydatin has demonstrated the ability to inhibit several enzymes involved in glucose, fatty acid, and cholesterol metabolism, while also curtailing the production of pro-inflammatory cytokines.


Polydatin (CAS 65914-17-2) References

  1. Protective effects of polydatin against CCl(4)-induced injury to primarily cultured rat hepatocytes.  |  Huang, ZS., et al. 1999. World J Gastroenterol. 5: 41-44. PMID: 11819383
  2. The mechanism of Polydatin in shock treatment.  |  Zhao, KS., et al. 2003. Clin Hemorheol Microcirc. 29: 211-7. PMID: 14724344
  3. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury.  |  Cheng, Y., et al. 2006. Brain Res. 1110: 193-200. PMID: 16870162
  4. Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters.  |  Du, J., et al. 2009. Phytomedicine. 16: 652-8. PMID: 19106037
  5. Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway.  |  Zhao, XJ., et al. 2018. Redox Biol. 18: 124-137. PMID: 30014902
  6. Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice.  |  Li, R., et al. 2018. Int J Biol Sci. 14: 1411-1425. PMID: 30262993
  7. Polydatin Prevents Lipopolysaccharide (LPS)-Induced Parkinson's Disease via Regulation of the AKT/GSK3β-Nrf2/NF-κB Signaling Axis.  |  Huang, B., et al. 2018. Front Immunol. 9: 2527. PMID: 30455692
  8. Targeting the ROS/PI3K/AKT/HIF-1α/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2-Deoxy-d-glucose.  |  Zhang, T., et al. 2019. J Cell Mol Med. 23: 3711-3723. PMID: 30920152
  9. Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt/β-catenin signaling pathway.  |  Chen, XJ., et al. 2019. Biomed Pharmacother. 112: 108746. PMID: 30970530
  10. Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting Ferroptosis.  |  Zhou, L., et al. 2022. Oxid Med Cell Longev. 2022: 9947191. PMID: 35075382
  11. Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies.  |  Schimith, LE., et al. 2022. Phytother Res. 36: 2852-2877. PMID: 35614539
  12. Pharmacological effects of polydatin in the treatment of metabolic diseases: A review.  |  Luo, J., et al. 2022. Phytomedicine. 102: 154161. PMID: 35636169
  13. Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits.  |  Karami, A., et al. 2022. Molecules. 27: PMID: 36235012
  14. Wine as a biological fluid: history, production, and role in disease prevention.  |  Soleas, GJ., et al. 1997. J Clin Lab Anal. 11: 287-313. PMID: 9292395

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Polydatin, 10 mg

sc-203203
10 mg
$92.00