Poly-L-Lysine Solution CAS: 25988-63-0
MW: 150,000-300,000

Poly-L-Lysine Solution (CAS 25988-63-0)

Poly-L-Lysine Solution | CAS 25988-63-0 is rated 4.7 out of 5 by 3.
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Application: Poly-L-Lysine Solution is an adhesive subbing solution for immunoperoxidase and routine histologic staining preparations
CAS Number: 25988-63-0
Molecular Weight: 150,000-300,000
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Poly-L-lysine is a positively charged amino acid polymer which has approximately one HBr per lysine residue. The hydrobromide allows the poly-L-lysine to be in a crystalline form which is soluble in water. A small amount of this product may be found in the beta structure because the HBr interferes with hydrogen bonding between amino and either the carboxyl groups or N or O containing moieties. Poly-L-lysine polymers can be used in promoting cell adhesion to solid substrates, conjugation to methotrexate for increased drug transport, microencapsulation of islets, cell microencapsulation technology, microarray glass slide coating, and chromosomal preparations.


References

1. Culling CFA, Allison RT, Bair WT: Cellular Pathology Technique, 4 th ed.
2. Butterworth & Co., Ltd Boston , 1985, p98 Theory and Practice of Histological Techniques
3. JD Bancroft, A Stevens, Editors, Churchill Livingston, New York , 1982, pp 75-76 Manual of H

Usage :
Poly-L-lysine can be used in promoting cell adhesion to solid substrates.
Formulation :
0.1 % (w/v) in H2O
Physical State :
Liquid
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
MDL Number :
MFCD00165424

Download SDS (MSDS)

Certificate of Analysis

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Poly-L-Lysine Solution (CAS 25988-63-0)  Product Citations

See how others have used Poly-L-Lysine Solution (CAS 25988-63-0). Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 29058362  Huang, C. et al. 2018. Glia. 66: 256-278.

PMID: # 29805628  Liu, ZG. et al. 2018. Oncol Lett. 15: 8935-8940.

PMID: # 29248540  Wang, P.|Zhang, Y.|Gong, Y.|Yang, R.|Chen, Z.|Hu, W.|Wu, Y.|Gao, M.|Xu, X.|Qin, Y.|Huang, C.| et al. 2018. Neurobiol. Dis. 111: 12-25.

PMID: # 26035224  Gautam, S. et al. 2015. Journal of the American Chemical Society. 137: 7441-7.

PMID: # 25483589  Wolff, NA. et al. 2014. Channels (Austin, Tex.). 8: 458-66.

PMID: # 32094207  J. Immunol. 204: 1954-1967.

PMID: # 32805217  J. Invest. Dermatol.

PMID: # 32423907  Life Sci Alliance. 3:

PMID: # 32332858  Commun Biol. 3: 196.

Citations 1 to 9 of 9 total

Does this product contain preservatives such as thimerosal?

Asked by: JR_NYC
Thank you for your question. Yes, this product contains 0.01% thimerosal as a preservative.
Answered by: Technical Support
Date published: 2020-03-11

Is this product suitable for cell culture use? Does it contain thimerosol or other preservative not suitable for cell culture?

Asked by: JR_NYC
This product has not been specifically tested for cell culture use and is not cell culture grade, however, most products can still be used in cell culture applications by following basic cell culture protocols, e.g. using cell culture grade/sterilized solvents, aseptic technique, and sterilely filtering in a sterile hood.
Answered by: Tech Service
Date published: 2020-03-04

Can you please provide a datasheet with RECOMMENDED COATING PROTOCOL and STORAGE AND RECONSTITUTION Thank you

Asked by: Researcher101
Thank you for your question. The concentration that this is supplied should be sufficient. Coating slides with this solution should be followed with a 5 minute incubation and drying the slides at room temperature. Coated slides will be stable for one year if protected from dust and stored according the MSDS conditions. Here is a link to a sample recent CoA and the SDS: http://datasheets.scbt.com/coa/coa.php?sc=sc-286689&lot=J2919 https://datasheets.scbt.com/sds/aghs/en/sc-286689.pdf
Answered by: Tech Service
Date published: 2020-02-20

Can this be used for tissue culture?

Asked by: Halle
Thank you very much for your inquiry. It has not been certified for cell culture. You can always run the solution through an appropriate filter if you want to sterilize it. Please do not hesitate to contact us again if you need any further information: [email protected]
Answered by: Technical Support Europe
Date published: 2018-06-07

What is the recommended concentration to use for plate coating?

Asked by: Jz28sail
Thank you for your question. sc-286689, Poly-L-Lysine Solution is supplied at 0.1 % (w/v) in water and is ready to use for coating slides or plates.
Answered by: Chemical Support 5
Date published: 2017-11-22
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Rated 4 out of 5 by from Perfecto!!! Los clientes están muy conformes con el producto.-
Date published: 2017-10-30
Rated 5 out of 5 by from Our lab uses this for IHC and good quality Our lab uses this for IHC and good quality solution.
Date published: 2015-10-07
Rated 5 out of 5 by from Various publications cite the use of Poly Various publications cite the use of Poly-L-Lysine Solution as an adhesive subbing solution for immunoperoxidase and routine histologic staining preparations. -SCBT Publication Review
Date published: 2015-03-28
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