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Poly-L-Lysine Hydrochloride (CAS 26124-78-7)

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Alternate Names:
PLL HCl
Application:
Poly-L-Lysine Hydrochloride is a polycation which binds to DNA
CAS Number:
26124-78-7
Molecular Weight:
15,000-30,000
Molecular Formula:
C6H14N2O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Poly-L-Lysine Hydrochloride is a synthetic amino acid polymer. It is a linear polymer composed of multiple L-Lysine units, a basic amino acid, linked together through peptide bonds. The hydrochloride salt form enhances its solubility in water, making it particularly useful in aqueous solutions. Poly-L-Lysine Hydrochloride acts as a facilitator for cell adhesion to solid surfaces, a property leveraged in cell culture technologies to improve the attachment, spread, and growth of various cell types on artificial substrates. Its positive charge at physiological pH levels interacts with negatively charged components on the cell membrane, promoting adherence and proliferation in a controlled environment.


Poly-L-Lysine Hydrochloride (CAS 26124-78-7) References

  1. Controlled gene delivery system based on thermosensitive biodegradable hydrogel.  |  Li, Z., et al. 2003. Pharm Res. 20: 884-8. PMID: 12817892
  2. Reversible configurational changes in poly-L-lysine hydrochloride induced by water.  |  BLOUT, ER. and LENORMANT, H. 1957. Nature. 179: 960-3. PMID: 13430748
  3. Architecturally induced multiresponsive vesicles from well-defined polypeptides: formation of gene vehicles.  |  Iatrou, H., et al. 2007. Biomacromolecules. 8: 2173-81. PMID: 17583949
  4. Structural changes of poly-L-lysine in solution and lyophilized form.  |  Kambara, O., et al. 2008. Phys Chem Chem Phys. 10: 5042-4. PMID: 18701950
  5. Interfacial energy of polypeptide complex coacervates measured via capillary adhesion.  |  Priftis, D., et al. 2012. Langmuir. 28: 8721-9. PMID: 22578030
  6. Considerations in binding diblock copolymers on hydrophilic alginate beads for providing an immunoprotective membrane.  |  Spasojevic, M., et al. 2014. J Biomed Mater Res A. 102: 1887-96. PMID: 23853069
  7. Polymersomes from polypeptide containing triblock Co- and terpolymers for drug delivery against pancreatic cancer: asymmetry of the external hydrophilic blocks.  |  Iatrou, H., et al. 2014. Macromol Biosci. 14: 1222-38. PMID: 24838730
  8. Reduction of the inflammatory responses against alginate-poly-L-lysine microcapsules by anti-biofouling surfaces of PEG-b-PLL diblock copolymers.  |  Spasojevic, M., et al. 2014. PLoS One. 9: e109837. PMID: 25347191
  9. Effects of surface-modifying ligands on the colloidal stability of ZnO nanoparticle dispersions in in vitro cytotoxicity test media.  |  Kwon, D., et al. 2014. Int J Nanomedicine. 9 Suppl 2: 57-65. PMID: 25565826
  10. Amino Acid Block Copolymers with Broad Antimicrobial Activity and Barrier Properties.  |  Bevilacqua, MP., et al. 2017. Macromol Biosci. 17: PMID: 28248002
  11. Water-induced conformational changes in the powder and film of ε-poly(L)lysine studied by infrared and Raman spectroscopy.  |  Nochi, M., et al. 2021. Spectrochim Acta A Mol Biomol Spectrosc. 260: 119900. PMID: 34004424
  12. Carbon-13 nuclear magnetic resonance studies of polyamino acids: the helix-coil transition of poly-L-lysine.  |  Saitô, H. and Smith, IC. 1973. Arch Biochem Biophys. 158: 154-63. PMID: 4729292
  13. Complexes of phosvitin with poly-L-lysine and protamine. Conformational analysis.  |  Perlmann, GE. and Grizzuti, K. 1971. Biochemistry. 10: 4168-76. PMID: 5126933

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Poly-L-Lysine Hydrochloride, 100 mg

sc-296118
100 mg
$388.00

Poly-L-Lysine Hydrochloride, 500 mg

sc-296118A
500 mg
$1543.00