Poly-L-Leucine (CAS 25322-63-8)
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Poly-L-Leucine is a polymer comprised of L-leucine, an essential amino acid. It can be used as a model to study protein folding or to modify the properties of surfaces in biotechnological applications. Some specific applications include biomaterial coating, biochip and biosensor development, antifouling surfaces, and affinity chromatography. Poly-L-Leucine can be used to coat surfaces of biomaterials to enhance their biocompatibility, reduce nonspecific protein adsorption, and improve cell attachment and proliferation. In biosensors or biochips, the polymer can be used to create specific domains or regions that attract or repel certain biomolecules, thereby enhancing the specificity and efficiency of the sensing mechanism. In marine applications, surfaces coated with Poly-L-Leucine might prevent or reduce the attachment of unwanted organisms. Additionally, the hydrophobic nature of Poly-L-Leucine can be leveraged in designing chromatography columns for the purification of specific proteins or other biomolecules.
Poly-L-Leucine (CAS 25322-63-8) References
- A silver-sulfadiazine-impregnated synthetic wound dressing composed of poly-L-leucine spongy matrix: an evaluation of clinical cases. | Kuroyanagi, Y., et al. 1992. J Appl Biomater. 3: 153-61. PMID: 10147712
- Possibility of wound dressing using poly(L-leucine)/poly(ethylene glycol)/poly(L-leucine) triblock copolymer. | Kim, HJ., et al. 2000. Biomaterials. 21: 131-41. PMID: 10632395
- Folding and translocation of the undecamer of poly-L-leucine across the water-hexane interface. A molecular dynamics study. | Chipot, C. and Pohorille, A. 1998. J Am Chem Soc. 120: 11912-24. PMID: 11542762
- SORPTION OF HYDROGEN CHLORIDE AND TRIFLUOROACETIC ACID ON POLY-L-VALINE AND POLY-L-LEUCINE. | BRANDT, WW. and BUDRYS, RS. 1964. J Biol Chem. 239: 1442-6. PMID: 14189877
- Kinetics of chalcone oxidation by peroxide anion catalysed by poly-l-leucine. | Carrea, G., et al. 2004. Chem Commun (Camb). 1412-3. PMID: 15179490
- pH-induced reversible conformational and morphological regulation of polyleucine grafted polyallylamine assembly in solution. | Higuchi, M., et al. 2005. Langmuir. 21: 11462-7. PMID: 16285826
- Polypeptide grafted hyaluronan: synthesis and characterization. | Wang, X., et al. 2010. Biomacromolecules. 11: 2313-20. PMID: 20690642
- Preparation and aggregation behavior of mannose-terminated poly(ethylene glycol)-b-poly(L-leucine) in water. | Wang, R., et al. 2011. Colloids Surf B Biointerfaces. 85: 56-62. PMID: 21144714
- Smart nanovehicles based on pH-triggered disassembly of supramolecular peptide-amphiphiles for efficient intracellular drug delivery. | Xu, X., et al. 2014. Small. 10: 1133-40. PMID: 24155260
- Synthesis of homopolypeptides by aminolysis mediated by proteases encapsulated in silica nanospheres. | Baker, PJ., et al. 2014. Macromol Biosci. 14: 1619-26. PMID: 25154484
- Synthesis and characterization of a hyperbranched grafting copolymer PEI-g-PLeu for gene and drug co-delivery. | Li, Y., et al. 2018. J Mater Sci Mater Med. 29: 47. PMID: 29687339
- Impact of Cationic Charge Density and PEGylated Poly(amino acid) Tercopolymer Architecture on Their Use as Gene Delivery Vehicles. Part 1: Synthesis, Self-Assembly, and DNA Complexation. | Ulkoski, D. and Scholz, C. 2018. Macromol Biosci. 18: e1800108. PMID: 29896863
- Chromatographic resolution of dipeptide enantiomers and diastereomers on chiral stationary phases from poly(L-leucine) or poly(L-phenylalanine). | Hirayama, C., et al. 1988. J Chromatogr. 450: 271-6. PMID: 3235592
- Raman scattering of some synthetic polypeptides: poly(gamma-benzyl L-glutamate), poly-L-leucine, poly-L-valine, and poly-L-serine. | Koenig, JL. and Sutton, PL. 1971. Biopolymers. 10: 89-106. PMID: 5544946
- Alpha-helical hydrophobic polypeptides form proton-selective channels in lipid bilayers. | Oliver, AE. and Deamer, DW. 1994. Biophys J. 66: 1364-79. PMID: 7520289
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Poly-L-Leucine, 50 mg | sc-296117 | 50 mg | $63.00 | |||
Poly-L-Leucine, 500 mg | sc-296117A | 500 mg | $344.00 |