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Poly(deoxyinosinic-deoxycytidylic) acid sodium salt (CAS 118578-37-3)

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Alternate Names:
Poly(deoxyinosinic-deoxycytidylic) acid sodium salt is also known as Poly(dI-dC) sodium salt.
Application:
Poly(deoxyinosinic-deoxycytidylic) acid sodium salt is a double-stranded alternating copolymer used to block nonspecific binding proteins.
CAS Number:
118578-37-3
Molecular Weight:
~2500000
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Poly(deoxyinosinic-deoxycytidylic) acid sodium salt (Poly(I:C))is a double-stranded alternating copolymer used in electrophoretic mobility shift assays to block nonspecific binding proteins. It can also be used as a nonspecific protein blocking agent in EMSA, a DNA substrate for evaluation of DNA methytransfeases, for conformational studies of DNA structure dynamics and drug, small molecule, interactions. Poly(deoxyinosinic-deoxycytidylic) acid sodium salt is also known as Poly(2′-deoxyinosinic-2′-deoxycytidylic acid).


Poly(deoxyinosinic-deoxycytidylic) acid sodium salt (CAS 118578-37-3) References

  1. The Fur-like protein Mur of Rhizobium leguminosarum is a Mn(2+)-responsive transcriptional regulator.  |  Díaz-Mireles, E., et al. 2004. Microbiology (Reading). 150: 1447-1456. PMID: 15133106
  2. Assaying cooperativity of protein-DNA interactions using agarose gel electrophoresis.  |  Williams, TL. and Levy, DL. 2013. Methods Mol Biol. 1054: 253-65. PMID: 23913298
  3. Pleiotropic functions of pituitary adenylyl cyclase-activating polypeptide on retinal ontogenesis: involvement of KLF4 in the control of progenitor cell proliferation.  |  Njaine, B., et al. 2014. J Mol Neurosci. 54: 430-42. PMID: 24715357
  4. The floral homeotic protein SEPALLATA3 recognizes target DNA sequences by shape readout involving a conserved arginine residue in the MADS-domain.  |  Käppel, S., et al. 2018. Plant J. 95: 341-357. PMID: 29744943

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Poly(deoxyinosinic-deoxycytidylic) acid sodium salt, 5 units

sc-286691
5 units
$192.00

Poly(deoxyinosinic-deoxycytidylic) acid sodium salt, 10 units

sc-286691A
10 units
$305.00

Poly(deoxyinosinic-deoxycytidylic) acid sodium salt, 25 units

sc-286691B
25 units
$610.00

Hi there! How we can convert Unit to mg?

Asked by: Maneli
Thank you for your question. The amount of mg per unit of Poly(deoxyinosinic-deoxycytidylic) acid sodium salt may vary from lot to lot. If you have already purchased the product you can download a lot-specific certificate of analysis by entering the lot number on the product page. Otherwise you can reach out to our technical service team for a CoA of the most recent lot of the compound.
Answered by: Tech Support Europe
Date published: 2023-12-22

How can I dilute the product (sc-286691) to get the final concentration 1 microgram/microlitre?

Asked by: Karn
Thank you for your question. This product is soluble in water or neutral buffer at 20 mg/ml.
Answered by: Technical Support
Date published: 2024-08-13

What is the average bp-length of the poly(dI-dC) ? 

Asked by: Biochem5B
Thank you for your question. This is lot specific information. Our most recent lot (F0917) has an approximate average length of 2046 bp.
Answered by: Technical Support
Date published: 2024-08-13

How stable is the product?

Asked by: chemsd02
Thank you for your question. sc-286691 (Poly(deoxyinosinic-deoxycytidylic) acid sodium salt, CAS 118578-37-3) is stable for 2-3 months when stored in solutions of water or buffer at -20ºC.
Answered by: Chemical Support 10
Date published: 2018-05-31

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. Poly(deoxyinosinic-deoxycytidylic) acid sodium salt, sc-286691, is soluble in water or neutral buffer at 20 mg/ml.
Answered by: TechService7
Date published: 2023-11-21
  • y_2026, m_4, d_2, h_10CST
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Rated 5 out of 5 by from How to convert 1 unit to mg?How to convert 1 unit to mg? 1 unit is equal to how many mg?
Date published: 2019-08-05
Rated 5 out of 5 by from It seems to work wellIt seems to work well! I've been using it as a blocking agent in EMSA assays and I don't have any problems with background.
Date published: 2015-04-08
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Poly(deoxyinosinic-deoxycytidylic) acid sodium salt is rated 5.0 out of 5 by 2.
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