Poly-D-Lysine: sc-136156

Poly-D-Lysine is a synthetic amino acid polymer widely utilized in the field of biotechnological and biochemical research, primarily due to its ability to promote cellular adhesion. Structurally, it consists of multiple D-lysine residues linked together through peptide bonds, forming a polycationic chain. This attribute is crucial as it allows for the formation of electrostatic interactions with negatively charged substances such as proteins, nucleic acids, and the phospholipid components of cell membranes. In scientific research, Poly-D-Lysine is employed as a coating substrate on various surfaces like glass and plastic to enhance the adhesion of a broad range of cell types. This functionality is particularly valuable in tissue culture applications, where the adherence of cells to the substrate is essential for successful growth, study, and manipulation in vitro. The polymer′s positive charge interacts with the negative charges on the cell surface, facilitating a more stable and uniform attachment of cells to the coated surface, thus improving cell morphology and proliferation. Moreover, Poly-D-Lysine serves a critical role in the study of cell behavior and characteristics under controlled conditions. It has been used in the examination of cellular processes such as migration, differentiation, and response to various stimuli. Its application extends into supporting the growth of neurons for neurological studies, which requires precise control over the cellular environment to mimic physiological conditions accurately. This makes Poly-D-Lysine a valuable tool in fundamental cellular and molecular biology research, contributing significantly to the understanding of complex biological systems.