Polistes Mastoparan CAS: 74129-19-4
MF: C77H127N21O18
MW: 1634.96
A binder and inhibitor of calmodulin.

Polistes Mastoparan (CAS 74129-19-4)

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Application: A binder and inhibitor of calmodulin
CAS Number: 74129-19-4
Molecular Weight: 1634.96
Molecular Formula: C77H127N21O18
* Refer to Certificate of Analysis for lot specific data (including water content).
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Polistes Mastoparan is a peptide found in wasp venom. It binds to and inhibits CAM (calmodulin), a calcium binding protein found in eukaryotic cells. It is suggested that a net positive charge on the peptide is important for anti-calmodulin activity because acetylation of the peptides is reported to reduce their inhibitory effect. It is also suggested that Polistes Mastoparan acts partly by stimulation of phospholipase activity.


References

1. Nakajima, T., et al. 1985. Peptides. 6: 425-430. PMID: 3831970
2. Barnette, M.S., et al. 1983. Biochem. Pharmacol. 32: 2929-2933. PMID: 6313011
3. Argiolas, A., et al. 1983. J. Biol. Chem. 258: 13697-13702. PMID: 6643447

Physical State :
Solid
Solubility :
Soluble in Ethanol
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16132143
SMILES :
CC[[email protected]](C)[[email protected]@H](C(=O)NCC(=O)N[[email protected]@H](CCC(=O)N)C(=O)N[[email protected]@H](CC1=CN=CN1)C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CO)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](CC(C)C)C(=O)N)NC(=O)[[email protected]](CCCCN)NC(=O)[[email protected]](CCCCN)NC(=O)[[email protected]](CC2=CNC3=CC=CC=C32)NC(=O)[[email protected]](CC(=O)O)NC(=O)[[email protected]](C(C)C)N

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Certificate of Analysis

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