Podophyllotoxin (CAS 518-28-5)
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Podophyllotoxin, a natural product derived from the roots and rhizomes of Podophyllum species, is a potent cytotoxic agent that has been extensively studied for its unique mechanism of action in various scientific contexts. The compound belongs to the lignan family and exhibits a fascinating chemical structure that enables it to interact with tubulin, an essential protein for cell division. The primary action of podophyllotoxin involves binding to tubulin at the colchicine-binding site, which leads to the inhibition of tubulin polymerization into microtubules. This disruption of microtubule assembly arrests cells in the metaphase of mitosis, leading to cell cycle arrest and, eventually, cell death. This mechanism is of particular interest in the study of cellular dynamics and the development of anti-mitotic agents. Beyond its interaction with tubulin, podophyllotoxin has been a subject of research in fields such as biochemistry and molecular biology. Scientists explore its role in inducing apoptosis (programmed cell death) through pathways that involve the activation of caspases and the depolarization of mitochondrial membranes. This aspect of podophyllotoxin research helps explain the broader impacts of microtubule disruption on cellular health and survival. In addition to its cellular effects, podophyllotoxin has been used as a lead compound for the synthesis of more complex derivatives in the study of structure-activity relationships. These derivatives aim to enhance the compound′s biological activity while minimizing potential toxicity. Research in this area involves modifying the podophyllotoxin scaffold to create new compounds that retain the ability to interfere with microtubule formation but have different physicochemical properties.
Podophyllotoxin (CAS 518-28-5) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Podophyllotoxin, 100 mg | sc-204853 | 100 mg | $84.00 |