Molecular structure of PNU 96415E, CAS Number: 170856-41-4
PNU 96415E (CAS 170856-41-4)
Alternate Names:
1-[2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride
Application:
PNU 96415E is a SR-2A inhibitor
CAS Number:
170856-41-4
Purity:
≥98%
Molecular Weight:
413.36
Molecular Formula:
C21H25FN2O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PNU 96415E is investigated in biochemical and neuroscientific research for its role as a serotonin receptor subtype 2A (5-HT2A) inhibitor. Interest in PNU 96415E stems from its potential to elucidate the physiological and pathophysiological roles of 5-HT2A receptors in the central nervous system. Studies employing PNU 96415E often aim to understand the modulation of serotonin signaling, which can influence a wide range of neurological processes and behaviors. The compound is also used to investigate the downstream effects of 5-HT2A receptor inhibition, such as changes in neurotransmitter release, neural circuitry, and cellular signaling pathways.
PNU 96415E (CAS 170856-41-4) References
- The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics? | Wadenberg, ML. and Hicks, PB. 1999. Neurosci Biobehav Rev. 23: 851-62. PMID: 10541060
- Dopamine D4 receptors and development of newer antipsychotic drugs. | Kulkarni, SK. and Ninan, I. 2000. Fundam Clin Pharmacol. 14: 529-39. PMID: 11206702
- Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. | Dolma, S., et al. 2016. Cancer Cell. 29: 859-873. PMID: 27300435
- Return of D4 Dopamine Receptor Antagonists in Drug Discovery. | Lindsley, CW. and Hopkins, CR. 2017. J Med Chem. 60: 7233-7243. PMID: 28489950
- Reprint of: A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth. | Pinheiro, T., et al. 2018. Biochem Biophys Res Commun. 499: 136-142. PMID: 29580626
- Understanding the role of dopamine in cancer: past, present and future. | Grant, CE., et al. 2022. Carcinogenesis. 43: 517-527. PMID: 35616105
- Therapeutic advantage of targeting lysosomal membrane integrity supported by lysophagy in malignant glioma. | Jing, Y., et al. 2022. Cancer Sci. 113: 2716-2726. PMID: 35657693
- PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties. | Tang, AH., et al. 1997. J Pharmacol Exp Ther. 281: 440-7. PMID: 9103528
- Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands. | Goudie, AJ., et al. 1998. Behav Pharmacol. 9: 699-710. PMID: 9890260
Inhibitor of:
SR-2A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PNU 96415E, 10 mg | sc-204852 | 10 mg | $125.00 | |||
PNU 96415E, 50 mg | sc-204852A | 50 mg | $525.00 |