Molecular structure of PNU-282987 hydrate, CAS Number: 123464-89-1 (anhydrous)
PNU-282987 hydrate (CAS 123464-89-1 (anhydrous))
Alternate Names:
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chloro-benzamide monohydrochloride
CAS Number:
123464-89-1 (anhydrous)
Purity:
≥98%
Molecular Weight:
301.21 (anhydrous basis)
Molecular Formula:
C14H17ClN2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PNU-282,987 is a highly selective agonist for the homomeric α7 nicotinic acetylcholine receptor (α7 nAChR). This novel agonist of the α7 nAChR has been utilized in multiple model brain investigations of this receptor. Utilizing rat hippocampal slices PNU-282,987 has been reported to evoke whole-cell currents. PNU-282,987 is hypothesized to modulate or enhance GABAergic hippocampal neurotransmission. Additionally, in mouse cerebellum, ethanol-induce ataxia was attenuated in a dose-dependant fashion with administration of PNU-282,987. PNU-282,987 has also been used in various studies to investigate the effects of the compound on hippocampal theta oscillation.
PNU-282987 hydrate (CAS 123464-89-1 (anhydrous)) References
- The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. | Hajós, M., et al. 2005. J Pharmacol Exp Ther. 312: 1213-22. PMID: 15523001
- Activation of alpha7 acetylcholine receptors augments stimulation-induced hippocampal theta oscillation. | Siok, CJ., et al. 2006. Eur J Neurosci. 23: 570-4. PMID: 16420464
- Pharmacological characterization of [(125)I]CHIBA-1006 binding, a new radioligand for α7 nicotinic acetylcholine receptors, to rat brain membranes. | Wu, J., et al. 2010. Brain Res. 1360: 130-7. PMID: 20816767
- α7 Nicotinic acetylcholine receptors in the central amygdaloid nucleus alter naloxone-induced withdrawal following a single exposure to morphine. | Ishida, S., et al. 2011. Psychopharmacology (Berl). 214: 923-31. PMID: 21125398
- The role of nicotinic acetylcholine receptor (nAChR) α7 subtype in the functional interaction between nicotine and ethanol in mouse cerebellum. | Taslim, N. and Saeed Dar, M. 2011. Alcohol Clin Exp Res. 35: 540-9. PMID: 21143250
- Selective α4β2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons. | Maloku, E., et al. 2011. Neuropsychopharmacology. 36: 1366-74. PMID: 21368748
- α7 nicotinic acetylcholine receptor agonist PNU-282987 attenuates early brain injury in a perforation model of subarachnoid hemorrhage in rats. | Duris, K., et al. 2011. Stroke. 42: 3530-6. PMID: 21960575
- Motor and anxiety effects of PNU-282987, an alpha7 nicotinic receptor agonist, and stress in an animal model of Alzheimer's disease. | Vicens, P., et al. 2013. Curr Alzheimer Res. 10: 516-23. PMID: 23566346
- The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice. | Stuckenholz, V., et al. 2013. J Parkinsons Dis. 3: 161-72. PMID: 23938346
- Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. | Kiss, T., et al. 2014. PLoS One. 9: e109538. PMID: 25303328
- Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury. | Dash, PK., et al. 2016. J Neurosci. 36: 2809-18. PMID: 26937017
- Alpha7 Nicotine Acetylcholine Receptor Agonist PNU-282987 Attenuates Acute Lung Injury in a Cardiopulmonary Bypass Model in Rats. | Ge, J., et al. 2017. Shock. 47: 474-479. PMID: 27661000
- Acute lung injury is reduced by the α7nAChR agonist PNU-282987 through changes in the macrophage profile. | Pinheiro, NM., et al. 2017. FASEB J. 31: 320-332. PMID: 27729414
- PNU-282987 Attenuates Intestinal Epithelial Barrier Dysfunction in LPS-Induced Endotoxemia. | Zhang, Y., et al. 2020. Inflammation. 43: 417-424. PMID: 31950323
- A Selective α7 Nicotinic Acetylcholine Receptor Agonist, PNU-282987, Attenuates ILC2s Activation and Alternaria-Induced Airway Inflammation. | Yuan, F., et al. 2020. Front Immunol. 11: 598165. PMID: 33597946
Activator of:
AChR α 7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PNU-282987 hydrate, 10 mg | sc-301554 | 10 mg | $139.00 |