Date published: 2025-10-18

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PNU 22394 hydrochloride (CAS 15923-78-1)

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Application:
PNU 22394 hydrochloride is a potent SR-2C agonist and partial SR-2A/SR-2B agonist
CAS Number:
15923-78-1
Molecular Weight:
236.74
Molecular Formula:
C13H16N2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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PNU 22394 hydrochloride is a potent SR-2C agonist and partial SR-2A/SR-2B agonist. It is non-selective between SR-2 subtypes. PNU 22394 hydrochloride reduces food intake in rats following subcutaneous administration and displays anorexigenic effects in humans.


PNU 22394 hydrochloride (CAS 15923-78-1) References

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  10. Serotonin is a key factor for mouse red blood cell survival.  |  Amireault, P., et al. 2013. PLoS One. 8: e83010. PMID: 24358245
  11. Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist.  |  Jensen, AA., et al. 2017. J Pharmacol Exp Ther. 361: 441-453. PMID: 28360333
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  14. Multiple-day administration of fosaprepitant combined with tropisetron and olanzapine improves the prevention of nausea and vomiting in patients receiving chemotherapy prior to autologous hematopoietic stem cell transplant: a retrospective study.  |  Ye, P., et al. 2022. Ann Hematol. 101: 1835-1841. PMID: 35668198
  15. Depressive patient-derived GABA interneurons reveal abnormal neural activity associated with HTR2C.  |  Lu, K., et al. 2023. EMBO Mol Med. 15: e16364. PMID: 36373384

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PNU 22394 hydrochloride, 10 mg

sc-204851
10 mg
$155.00

PNU 22394 hydrochloride, 50 mg

sc-204851A
50 mg
$615.00