Molecular structure of Pluviatolide, CAS Number: 28115-68-6
Pluviatolide (CAS 28115-68-6)
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Alternate Names:
(−)-Pluviatolide
Application:
Pluviatolide is a butyrolactone lignan that exhibits antispasmodic effects
CAS Number:
28115-68-6
Purity:
≥95%
Molecular Weight:
356.4
Molecular Formula:
C20H20O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pluviatolide, a compound that can be found in the roots of Podophyllum hexandrum, exhibits a diverse range of bioactivities, including anti-inflammatory, cytotoxic, and antitumor effects. It possesses two chiral centers, making it an enantiopure compound. Achieving the desired enantiomer requires undergoing asymmetric synthesis. While the complete biosynthesis of pluviatolide remains elusive, research suggests that p450 enzymes play a significant role in its formation. Furthermore, various chemical structures have been isolated from pluviatolide, including secoisolariciresinol, which shares structural similarities with pluviatolide.
Pluviatolide (CAS 28115-68-6) References
- Biosynthesis of yatein in Anthriscus sylvestris. | Sakakibara, N., et al. 2003. Org Biomol Chem. 1: 2474-85. PMID: 12956064
- Inhibitory effects of lignans on the activity of human matrix metalloproteinase 7 (matrilysin). | Muta, Y., et al. 2004. J Agric Food Chem. 52: 5888-94. PMID: 15366838
- Chemical constituents of Aristolochia constricta: antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid. | Zhang, G., et al. 2008. J Nat Prod. 71: 1167-72. PMID: 18570470
- Next generation sequencing in predicting gene function in podophyllotoxin biosynthesis. | Marques, JV., et al. 2013. J Biol Chem. 288: 466-79. PMID: 23161544
- Expression analysis of biosynthetic pathway genes vis-à-vis podophyllotoxin content in Podophyllum hexandrum Royle. | Kumar, P., et al. 2015. Protoplasma. 252: 1253-62. PMID: 25586110
- Chemical constituents from Mongolian herb Syringa pinnatifolia var. alashanensis. | Lu, P., et al. 2015. Chin J Nat Med. 13: 142-4. PMID: 25769897
- Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone. | Lau, W. and Sattely, ES. 2015. Science. 349: 1224-8. PMID: 26359402
- Comparative whole-transcriptome analysis in Podophyllum species identifies key transcription factors contributing to biosynthesis of podophyllotoxin in P. hexandrum. | Kumar, P., et al. 2017. Protoplasma. 254: 217-228. PMID: 26733390
- Assembly of Plant Enzymes in E. coli for the Production of the Valuable (-)-Podophyllotoxin Precursor (-)-Pluviatolide. | Decembrino, D., et al. 2020. ACS Synth Biol. 9: 3091-3103. PMID: 33095000
- Transgenic Forsythia plants expressing sesame cytochrome P450 produce beneficial lignans. | Koyama, T., et al. 2022. Sci Rep. 12: 10152. PMID: 35710718
- A targeted metabolomics method for extra- and intracellular metabolite quantification covering the complete monolignol and lignan synthesis pathway. | Steinmann, A., et al. 2022. Metab Eng Commun. 15: e00205. PMID: 36119807
- Two O-Methyltransferases from Phylogenetically Unrelated Cow Parsley (Anthriscus sylvestris) and Hinoki-Asunaro (Thujopsis dolabrata var. hondae) as a Signature of Lineage-Specific Evolution in Lignan Biosynthesis. | Yamamura, M., et al. 2023. Plant Cell Physiol. 64: 124-147. PMID: 36412832
- Antibiotic activity and absolute configuation of 8S-heptadeca-2(Z),9(Z)-diene-4,6-diyne-1,8-diol from Bupleurum salicifolium. | Estevez-Braun, A., et al. 1994. J Nat Prod. 57: 1178-82. PMID: 7964800
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pluviatolide, 1 mg | sc-506426 | 1 mg | $241.00 |