(+)-Potassium DS-threo-isocitrate monobasic (CAS 20226-99-7)

(+)-Potassium DS-threo-isocitrate monobasic, belonging to the family of alpha-hydroxy acids, serves as a substrate for the characterization of isocitrate dehydrogenase. This chemical compound is an important intermediate in the citric acid cycle, a vital metabolic pathway found in all living organisms. Extensive studies have explored the diverse potential applications of (+)-Potassium DS-threo-isocitrate monobasic across various fields. (+)-Potassium DS-threo-isocitrate monobasic has demonstrated antioxidant, anti-inflammatory, and anti-cancer properties in vitro. Agriculture studies have shown that (+)-Potassium DS-threo-isocitrate monobasic can improve plant growth, enhance yield, and boost plant resilience against environmental stressors. Within the food industry, this compound has found applications as a natural preservative, flavor enhancer, and acidulant. The biological effects of (+)-Potassium DS-threo-isocitrate monobasic stem from its modulation of various cellular signaling pathways. Activation of the AMP-activated protein kinase (AMPK) pathway, which governs energy metabolism and cellular stress response, has been observed. Additionally, this compound inhibits the activity of the nuclear factor-kappa B (NF-κB) pathway, which plays a role in inflammation and immune response. Furthermore, (+)-Potassium DS-threo-isocitrate monobasic influences enzymes involved in carbohydrate and lipid metabolism, such as pyruvate dehydrogenase and acetyl-CoA carboxylase.