Molecular structure of (+)-MK 801 maleate, CAS Number: 77086-22-7
(+)-MK 801 maleate (CAS 77086-22-7)
Alternate Names:
(+)-MK 801 maleate is also known as Dizocilpine maleate.
Application:
(+)-MK 801 maleate is a highly potent, selective, and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist.
CAS Number:
77086-22-7
Purity:
≥98%
Molecular Weight:
337.37
Molecular Formula:
C16H15N•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(+)-MK 801 maleate is a selective non-competitive antagonist of the NMDA receptor. (+)-MK 801 is described to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction. (+)-MK 801 maleate may act to be protective in various models of ischemia as well as to inhibit behavioral sensitization to certain psychostimulants.
(+)-MK 801 maleate (CAS 77086-22-7) References
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- Adenosine and astrocytes determine the developmental dynamics of spike timing-dependent plasticity in the somatosensory cortex. | Martínez-Gallego, I., et al. 2022. J Neurosci. 42: 6038-52. PMID: 35768208
- Synaptotagmin-1 is a Ca2+ sensor for somatodendritic dopamine release. | Lebowitz, JJ., et al. 2023. Cell Rep. 42: 111915. PMID: 36640316
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Inhibitor of:
NMDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(+)-MK 801 maleate, 10 mg | sc-203137 | 10 mg | $100.00 | |||
(+)-MK 801 maleate, 50 mg | sc-203137A | 50 mg | $350.00 | |||
(+)-MK 801 maleate, 100 mg | sc-203137B | 100 mg | $510.00 | |||
(+)-MK 801 maleate, 250 mg | sc-203137C | 250 mg | $1015.00 |