Molecular structure of (±)-U-50488 hydrochloride, CAS Number: 67197-96-0
(±)-U-50488 hydrochloride (CAS 67197-96-0)
Alternate Names:
methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Application:
(±)-U-50488 hydrochloride is a selective κ-opioid agonist
CAS Number:
67197-96-0
Purity:
≥98%
Molecular Weight:
405.8
Molecular Formula:
C19H26Cl2N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
(±)-U-50488 hydrochloride is a selective KOR (kappa-opioid) agonist. (±)-U-50488 hydrochloride also blocks Na+ channels at higher concentrations. (±)-U-50488 hydrochloride is an inhibitor of Calcium Channel Protein.
(±)-U-50488 hydrochloride (CAS 67197-96-0) References
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- Depression of C fibre-evoked spinal field potentials by the spinal delta opioid receptor is enhanced in the spinal nerve ligation model of neuropathic pain: involvement of the mu-subtype. | Buesa, I., et al. 2008. Neuropharmacology. 55: 1376-82. PMID: 18775732
- Attenuation of cocaine's reinforcing and discriminative stimulus effects via muscarinic M1 acetylcholine receptor stimulation. | Thomsen, M., et al. 2010. J Pharmacol Exp Ther. 332: 959-69. PMID: 19996296
- Opioidergic modulation of ethanol self-administration in the ventral pallidum. | Kemppainen, H., et al. 2012. Alcohol Clin Exp Res. 36: 286-93. PMID: 21895714
- Differential modulation of gonadotropin responses to kisspeptin by aminoacidergic, peptidergic, and nitric oxide neurotransmission. | García-Galiano, D., et al. 2012. Am J Physiol Endocrinol Metab. 303: E1252-63. PMID: 23011064
- A cell-based, high-throughput homogeneous time-resolved fluorescence assay for the screening of potential κ-opioid receptor agonists. | Wang, Y., et al. 2014. Acta Pharmacol Sin. 35: 957-66. PMID: 24930486
- κ-opioid receptor as a key mediator in the regulation of appetitive 50-kHz ultrasonic vocalizations. | Hamed, A., et al. 2015. Psychopharmacology (Berl). 232: 1941-55. PMID: 25466704
- Accumbal μ-Opioid Receptors Modulate Ethanol Intake in Alcohol-Preferring Alko Alcohol Rats. | Uhari-Väänänen, J., et al. 2016. Alcohol Clin Exp Res. 40: 2114-2123. PMID: 27508965
- Sex Differences in the Effects of a Kappa Opioid Receptor Antagonist in the Forced Swim Test. | Laman-Maharg, A., et al. 2018. Front Pharmacol. 9: 93. PMID: 29491835
- Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells. | Stoeber, M., et al. 2020. Elife. 9: PMID: 32096468
- Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion. | Wei, YY., et al. 2022. Acta Pharmacol Sin. 43: 1372-1382. PMID: 34493813
- Antinociceptive activities and mechanism of action of Cepharanthine. | Wei, XY., et al. 2022. Biochem Biophys Res Commun. 614: 219-224. PMID: 35636221
Inhibitor of:
Calcium Channel Protein.Activator of:
KOR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-U-50488 hydrochloride, 1 mg | sc-203713 | 1 mg | $101.00 |