Molecular structure of (±)-Phenylsuccinic acid, CAS Number: 635-51-8
(±)-Phenylsuccinic acid (CAS 635-51-8)
Alternate Names:
Phenylsuccinic acid
CAS Number:
635-51-8
Molecular Weight:
194.18
Molecular Formula:
C10H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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(±)-Phenylsuccinic acid, a dicarboxylic acid derived from benzene, possesses two carboxylic acid groups. It has garnered attention as an inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), in pyrimidine nucleotide metabolism. Notably, (±)-Phenylsuccinic acid has exhibited inhibitory effects on cancer cell growth in vitro. In the realm of inflammation research, its potential in modulating the activity of nuclear factor kappa B (NF-κB), a key transcription factor in the inflammatory response, has been explored. Research findings indicate that (±)-Phenylsuccinic acid effectively hinders NF-κB activity.
(±)-Phenylsuccinic acid (CAS 635-51-8) References
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- Enantioseparation of phenylsuccinic acid by high speed counter-current chromatography using hydroxypropyl-β-cyclodextrin as chiral selector. | Tong, S., et al. 2011. J Chromatogr A. 1218: 5602-8. PMID: 21752382
- Separation of phenylsuccinic acid enantiomers using biphasic chiral recognition high-speed countercurrent chromatography. | Sun, G., et al. 2014. J Sep Sci. 37: 1736-41. PMID: 24788958
- Enantioselective extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and β-cyclodextrin derivative: Modeling and optimization through response surface methodology. | Wang, J., et al. 2016. J Chromatogr A. 1467: 490-496. PMID: 27372416
- Chiral Separations by Countercurrent Chromatography. | Tong, SQ. 2019. Methods Mol Biol. 1985: 321-337. PMID: 31069742
- Stable Chitosan-Based Nanoparticles Using Polyphosphoric Acid or Hexametaphosphate for Tandem Ionotropic/Covalent Crosslinking and Subsequent Investigation as Novel Vehicles for Drug Delivery. | Saeed, RM., et al. 2020. Front Bioeng Biotechnol. 8: 4. PMID: 32039190
- Hydroxypropyl-β-cyclodextrin encapsulated stationary phase based on silica monolith particles for enantioseparation in liquid chromatography. | Lu, Y. and Sun, G. 2021. J Sep Sci. 44: 735-743. PMID: 33253443
- Efficient carboxylation of styrene and carbon dioxide by single-atomic copper electrocatalyst. | Quan, Y., et al. 2021. J Colloid Interface Sci. 601: 378-384. PMID: 34087598
- Synthesis and properties of cyclic derivatives of phenylsuccinic acid. IX. New phenylsuccinimide derivatives with anticonvulsant properties. | Lange, J., et al. 1987. Acta Pol Pharm. 44: 249-54. PMID: 3447414
- Lipase-based MIL-100(Fe) biocomposites as chiral stationary phase for high-efficiency capillary electrochromatographic enantioseparation. | Sun, G., et al. 2023. Mikrochim Acta. 190: 84. PMID: 36749401
- Soft drugs. 13: Design and evaluation of phenylsuccinic analogs of scopolamine as soft anticholinergics. | Kumar, GN., et al. 1993. Drug Des Discov. 10: 1-9. PMID: 8399990
- Synthesis of N-alkyloamino- or arylo-imide derivatives of succinic acid. | Lucka-Sobstel, B., et al. 1977. Arch Immunol Ther Exp (Warsz). 25: 285-9. PMID: 869683
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-Phenylsuccinic acid, 100 g | sc-250708 | 100 g | $79.00 |