(±)-Octanoylcarnitine chloride (CAS 18822-86-1)

(±)-Octanoylcarnitine chloride (OCC) is a homolog of acetylcarnitine chloride (sc-203495). Acylcarnitines are important intermediates in lipid metabolism. (±)-Octanoylcarnitine chloride is synthesized by the esterification of octanoic acid with carnitine, and it has been extensively studied for its biochemical and physiological effects, particularly in the field of metabolism and energy production. It may act to enhance fatty acid oxidation, increase energy expenditure, improve insulin sensitivity, and have neuroprotective effects. The effects of (±)-Octanoylcarnitine chloride are exerted through the enhancement of the acylcarnitine pool, thereby facilitating the transportation of long-chain fatty acids into the mitochondria for the process of β-oxidation. Furthermore, this compound activates the peroxisome proliferator-activated receptor alpha (PPARα), a transcription factor responsible for regulating the expression of genes engaged in fatty acid metabolism and the generation of energy. Additionally, (±)-Octanoylcarnitine chloride has been observed to impede the activity of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the transformation of acetyl-CoA into malonyl-CoA. This transformation is a pivotal regulatory step in the process of fatty acid oxidation.