Molecular structure of (±)-Naringenin, CAS Number: 67604-48-2
(±)-Naringenin (CAS 67604-48-2)
See product citations (1)
Alternate Names:
4′,5,7-Trihydroxyflavanone; (±)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4- one
Application:
(±)-Naringenin is a PI 3-kinase inhibitor
CAS Number:
67604-48-2
Purity:
≥95%
Molecular Weight:
272.30
Molecular Formula:
C15H12O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)-Naringenin is an antioxidant flavonoid found in citrus fruits with anti-inflammatory, anti-allergic, and antitumor properties. It induces apoptosis, stimulates DNA repair following oxidative damage, and inhibits the activity of PI 3-kinase (PI(3)K). (±)-Naringenin activates the PPAR-γ receptor, which is involved in regulating glucose metabolism, lipid metabolism, and inflammation. It also binds to and activates the sirtuin-1 receptor, which is involved in regulating inflammation, oxidative stress, and cell death. In addition, it may act to inhibit the activity of a number of enzymes, including cyclooxygenase-2, lipoxygenase, and matrix metalloproteinases.
(±)-Naringenin (CAS 67604-48-2) References
- Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes. | Harmon, AW. and Patel, YM. 2003. Biochem Biophys Res Commun. 305: 229-34. PMID: 12745063
- The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells. | Gao, K., et al. 2006. J Nutr Biochem. 17: 89-95. PMID: 16111881
- Naringenin-induced apoptosis via activation of NF-kappaB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells. | Kanno, S., et al. 2006. Toxicol Lett. 166: 131-9. PMID: 16860949
- Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. | Hirai, S., et al. 2007. Life Sci. 81: 1272-9. PMID: 17915259
- Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice. | Wang, Q., et al. 2020. Br J Pharmacol. 177: 1806-1821. PMID: 31758699
- Naringenin loaded multifunctional nanoparticles to enhance the chemotherapeutic efficacy in hepatic fibrosis. | Yang, F., et al. 2020. Biomed Microdevices. 22: 68. PMID: 32955605
- Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe-/-mice: role of SIRT1. | Hua, YQ., et al. 2021. Phytomedicine. 81: 153412. PMID: 33234364
- The Effects of Naringenin on miRNA-mRNA Profiles in HepaRG Cells. | Fan, W., et al. 2021. Int J Mol Sci. 22: PMID: 33669020
- Preparation, characterization of naringenin, β-cyclodextrin and carbon quantum dot antioxidant nanocomposites. | Liang, Y., et al. 2022. Food Chem. 375: 131646. PMID: 34848084
- Naringenin affords protection against lipopolysaccharide/D-galactosamine-induced acute liver failure: Role of autophagy. | Ahmedy, OA., et al. 2022. Arch Biochem Biophys. 717: 109121. PMID: 35065059
- Naringenin promoted spinal microglia M2 polarization in rat model of cancer-induced bone pain via regulating AMPK/PGC-1α signaling axis. | Ge, MM., et al. 2022. Biomed Pharmacother. 149: 112912. PMID: 35856853
- Naringenin suppresses BEAS-2B-derived extracellular vesicular cargoes disorder caused by cigarette smoke extract thereby inhibiting M1 macrophage polarization. | Chen, Z., et al. 2022. Front Immunol. 13: 930476. PMID: 35924248
- [Naringenin inhibits thoracic aortic aneurysm formation in mice with Marfan syndrome]. | Li, ZQ., et al. 2022. Beijing Da Xue Xue Bao Yi Xue Ban. 54: 896-906. PMID: 36241232
- Naringenin Microsphere as a Novel Adjuvant Reverses Colistin Resistance via Various Strategies against Multidrug-Resistant Klebsiella pneumoniae Infection. | Sheng, Q., et al. 2022. J Agric Food Chem. 70: 16201-16217. PMID: 36530172
- Structure-antioxidant activity relationships of flavonoids and phenolic acids. | Rice-Evans, CA., et al. 1996. Free Radic Biol Med. 20: 933-56. PMID: 8743980
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-Naringenin, 1 g | sc-203155 | 1 g | $47.00 | |||
(±)-Naringenin, 5 g | sc-203155A | 5 g | $89.00 | |||
(±)-Naringenin, 25 g | sc-203155B | 25 g | $161.00 | |||
(±)-Naringenin, 100 g | sc-203155C | 100 g | $317.00 | |||
(±)-Naringenin, 500 g | sc-203155D | 500 g | $837.00 |